29119-40-2

Upstream product

• 29127-96-6 p-Toluolsulfonylazostilben 
• 62398-10-1 2-acetoxy-2-phenylacetophenone 
• 24854-36-2 C₂₃H₂₂N₂O₄S 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 501-65-5 diphenyl acetylene 
• 5395-20-0 1-methyl-4-(benzylsulfonyl)benzene 
• 657-84-1 sodium tosylate 
• 19816-85-4 N'-(1,2-diphenylethylidene)-4-methylbenzenesulfonohydrazide 

Downstream Products

• 646450-29-5 C₂₁H₁₆O₂S 
• 501-65-5 diphenyl acetylene 

Relevant academic research and scientific papers

A synthetic E - alkene base sulphone compounds

The invention discloses a method for synthesizing an E-alkenyl sulfone compound, which comprises the following steps: dissolving phenylsulfonyl hydrazone in a DMF (N,N-dimethylformamide) solvent, adding iodobenzene diacetate and potassium carbonate, and r

PhI(OAc)2-mediated decomposition of N-arylsulfonyl hydrazones: metal-free synthesis of (E)-vinyl sulfones

A novel and efficient approach for the preparing of (E)-vinyl sulfones via PhI(OAc)2-mediated decomposition of ketone-derived N-arylsulfonyl hydrazones has been developed. The generation of α- or β-substituted vinyl sulfones was affected by the

Copper-catalyzed radical reaction of N -tosylhydrazones: Stereoselective synthesis of (E)-vinyl sulfones

A new chemistry of hydrazines that is a copper-catalyzed radical reaction to synthesize vinyl sulfones from readily available N-tosylhydrazones has been described. The protocol provides a novel strategy for the synthesis of various vinyl sulfones including α, β-disubstituted ones and terminal ones. The advantages of the transformation include excellent E stereoselectivity, broad substrate scope, low cost of reagents, and convenient operation. A novel and efficient one-pot synthesis of alkynes from N-tosylhydrazones has been achieved. The studies provide important complementary approaches for the syntheses of vinyl sulfones and alkynes.

Regioselective Synthesis of Vinyl Halides, Vinyl Sulfones, and Alkynes: A Tandem Intermolecular Nucleophilic and Electrophilic Vinylation of Tosylhydrazones

A diazo species is trapped in an intermolecular fashion by two independent ion species in tandem at the carbene center to install an electrophile and a nucleophile on the same carbon. This metal-free concept, which is unprecedented, has been illustrated by regioselective synthesis of a variety of vinyl halides, vinyl sulfones, and alkyne derivatives. (Chemical Equation Presented).

Aerobic copper-catalyzed synthesis of (E)-alkenyl sulfones and (E)-β-halo-alkenyl sulfones via addition of sodium sulfinates to alkynes

Copper-catalyzed sulfonylation of alkynes using sodium sulfinates in air produced regio- and stereoselectively (E)-alkenyl sulfones. When a CuCl catalyst was employed, the hydrosulfonylation proceeded syn-selectively, and (E)-alkenyl sulfones were synthesized in excellent yields. In contrast, the reaction using CuI catalyst produced (E)-β-haloalkenyl sulfones anti-selectively in the presence of potassium halides. Furthermore, the (E)-β-bromoalkenyl sulfones are possible to convert into various alkenyl sulfones by Suzuki-Miyaura coupling.

One-pot synthesis of sulfonyl (E)-stilbenes by nitrobenzene-mediated dimerizative desulfonation of benzylic sulfones

A facile one-pot synthetic route for preparing sulfonyl (E)-stilbenes 4 is developed. The efficient route is realized by a nitrobenzene (PhNO 2)-mediated dimerizative desulfonation of benzylic sulfones 3 in the presence of sodium hydride (NaH) in good yields. Some synthetic investigations of sulfonyl stilbenes 4 are also examined.

Copper-catalyzed oxidative hydrosulfonylation of alkynes using sodium sulfinates in air

Copper-catalyzed hydrosulfonylations of alkynes can be carried out using sodium sulfinates in air. The procedure affords syn-selectively (E)-alkenyl sulfones in good yields. Then, both terminal and internal alkynes are available. Georg Thieme Verlag Stuttgart · New York.