29146-63-2

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-HYDROXY-PROPYL)-3-PHENYL-THIOUREA is used as an antifungal and antibacterial agent for its potential to inhibit the growth of certain microorganisms, contributing to the development of new treatments for infections.
Used in Anticancer Research:
In the field of oncology, 1-(3-HYDROXY-PROPYL)-3-PHENYL-THIOUREA is used as a compound under investigation for its ability to inhibit the growth of certain tumor cells, offering a potential avenue for the development of novel anticancer drugs.
Used in Agricultural Industry:
1-(3-HYDROXY-PROPYL)-3-PHENYL-THIOUREA is used as a potential bioactive agent in agriculture, where it may contribute to the control of fungal and bacterial diseases affecting crops, thereby enhancing crop health and productivity.
Used in Organic Synthesis:
Due to its unique structure and reactivity, 1-(3-HYDROXY-PROPYL)-3-PHENYL-THIOUREA is used as a building block in the synthesis of other organic compounds, which could have applications in various chemical and material science domains.

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 156-87-6 propan-1-ol-3-amine 
• 62-53-3 aniline 
• 94407-77-9 S-phenylthiocarbamoyl-thiocarbonic acid O-ethyl ester 
• 43009-16-1 phenyldithiocarbamic acid triethylamine salt 

Downstream Products

• 66268-31-3 2-aminophenyl-5,6-dihydro-(4H)-1,3-thiazine 
• 3420-40-4 N-(4,5-dihydro-3-methyl-1,3-thiazine-2-ylidene)aniline 
• 958300-69-1 3-(3-hydroxypropyl)-2-phenylimino-4-thiazolidinone 
• 34117-49-2 2,3,4-Trihydro-1,3-thiazino<3,2-a>benzimidazole 
• 29199-79-9 1-(3-Hydroxy-propyl)-2-methyl-3-phenyl-isothiourea; hydriodide 

Relevant academic research and scientific papers

Novel non-peptidic small molecule inhibitors of secreted aspartic protease 2 (SAP2) for the treatment of resistant fungal infections

Targeting secreted aspartic protease 2 (SAP2), a kind of virulence factor, represents a new strategy for antifungal drug discovery. In this report, the first-generation of small molecule SAP2 inhibitors was rationally designed and optimized using a structure-based approach. In particular, inhibitor 23h was highly potent and selective and showed good antifungal potency for the treatment of resistant Candida albicans infections.

A Bench-Stable Vilsmeier Reagent for in situ Alcohol Activation: Synthetic Application in the Synthesis of 2-Amino-2-Thiazolines

A robust, chemoselective direct condensation/cyclization of thioureas and amino alcohols is described. Employing a bench-stable Vilsmeier reagent, methoxymethylene- N, N -dimethyliminium methyl sulfate, the selective in situ activation of alcohols is achieved with high efficiency and broad functional-group tolerance. The reversible interaction of the Vilsmeier reagent with substrate was key to the success of this activation strategy.

Synthesis of benzimidazole-fused heterocycles by intramolecular oxidative C-N bond formation using hypervalent iodine reagents

A straightforward approach by dehydrogenative C-N coupling between aryl C-H and N-H bonds using a hypervalent iodine reagent under mild conditions offers a versatile and convenient method for synthesizing various benzimidazole-fused heterocycles. Georg Th

A convenient method for the synthesis of 2-amino substituted aza-heterocycles from N,N′-disubstituted thioureas using TsCl/NaOH

p-Toluenesulfonyl chloride (TsCl)/NaOH has been introduced as reagent combination for the synthesis of 2-amino-oxa- or 2-amino-thiazolidines from N-(2-hydroxyethyl)-thioureas, but its general application in heterocycle synthesis has not been investigated. In this paper the convenient and efficient synthesis of a variety of 2-amino-substituted 1-aza 3-(aza, oxo or thio) heterocycles of different substitution and ring sizes is described. The application of polymer-supported TsCl facilitates work-up and renders the reaction conditions very suitable for parallel or robot synthesis. Graphical Abstract

Process for synthesizing heterocyclic compounds

The invention provides the process illustrated in scheme 1 for synthesizing heterocyclic compounds of formula I. In the process, an isothiocyanate of formula II is initially reacted with a primary amine of formula III to give a thiourea of formula IV. Subsequently, the thiourea of formula IV is converted to the corresponding heterocycle of formula I using a base and a sulfonyl chloride.

Aminothiazines et aminothiazoles analogues ouverts du levamisole: synthese et approche du mode d'action nematicide

New compounds with thiazoline or dihydrothiazine rings substituted by alkylamino or arylamino groups were synthesized and screened in vitro against three Nematodes.Inhibition of fumarate-reductase activity was also evaluated.For all in vitro anti-parasitic tests, dihydrothiazines were more potent than corresponding thiazolines derivatives, however, thiazolines showed a greater inhibition of fumarate-reductase.