66268-31-3Relevant academic research and scientific papers
Synthesis of Diaryl Diazaphosphonates via 1,6-Hydrophosphonylation of p-Quinone Methides with N-Heterocyclic Phosphine-Thioureas
Molleti, Nagaraju,Kang, Jun Yong
supporting information, p. 958 - 961 (2017/02/26)
A mild, efficient method for the synthesis of diaryl diazaphosphonates via 1,6-hydrophosphonylation/aromatization of p-quinone methides (p-QMs) with N-heterocyclic phosphine-thioureas has been developed. This transformation proceeds without any additive or catalyst under mild reaction conditions and tolerates a wide range of p-QMs. This methodology provides a straightforward access to diaryl phosphonate derivatives in good to excellent yields (up to 99%).
A Bench-Stable Vilsmeier Reagent for in situ Alcohol Activation: Synthetic Application in the Synthesis of 2-Amino-2-Thiazolines
Corbett, Michael T.,Caille, Seb
, p. 2845 - 2850 (2017/10/06)
A robust, chemoselective direct condensation/cyclization of thioureas and amino alcohols is described. Employing a bench-stable Vilsmeier reagent, methoxymethylene- N, N -dimethyliminium methyl sulfate, the selective in situ activation of alcohols is achieved with high efficiency and broad functional-group tolerance. The reversible interaction of the Vilsmeier reagent with substrate was key to the success of this activation strategy.
Synthesis of benzimidazole-fused heterocycles by intramolecular oxidative C-N bond formation using hypervalent iodine reagents
Kutsumura, Noriki,Kunimatsu, Shinichi,Kagawa, Kimiko,Otani, Takashi,Saito, Takao
, p. 3235 - 3240 (2011/11/30)
A straightforward approach by dehydrogenative C-N coupling between aryl C-H and N-H bonds using a hypervalent iodine reagent under mild conditions offers a versatile and convenient method for synthesizing various benzimidazole-fused heterocycles. Georg Th
Selenium-containing heterocycles from isoselenocyanates: Synthesis of 1,3-selenazolidine and perhydro-1,3-selenazine derivatives
Sommen, Geoffroy L.,Linden, Anthony,Heimgartner, Heinz
, p. 3128 - 3137 (2007/10/03)
Treatment of ω-halo alkylamines 9 and 10 with aryl and alkyl isoselenocyanates 6a-g in the presence of triethylamine in dichloromethane gave the corresponding 1,3-selenazolidines 11a-g and perhydro-1,3-selenazines 12a-g, respectively, in good to excellent
Aminothiazines et aminothiazoles analogues ouverts du levamisole: synthese et approche du mode d'action nematicide
Caujolle, Raymond,Amarouch, Hamid,Payard, Marc,Loiseau, Philippe R.,Bories, Christian,et al.
, p. 287 - 292 (2007/10/02)
New compounds with thiazoline or dihydrothiazine rings substituted by alkylamino or arylamino groups were synthesized and screened in vitro against three Nematodes.Inhibition of fumarate-reductase activity was also evaluated.For all in vitro anti-parasitic tests, dihydrothiazines were more potent than corresponding thiazolines derivatives, however, thiazolines showed a greater inhibition of fumarate-reductase.
TRANSFORMATIONS OF PYRIDINIUMS DERIVED FROM AMINO-ALCOHOLS AND FROM DIAMINES
Katritzky, Alan R.,Langthorne, Roland T.,Patel, Ranjan C.,Lhommet, Gerard
, p. 2383 - 2390 (2007/10/02)
Pyridiniums derived from amino alcohols cyclise to ethers or rearrange to aldehydes on heating.Monopyridiniums from diamines can be acylated or converted into ureas or thioureas: these products cyclise on heating in solution to give dihydro-thiazoles, -4H-thiazines, -oxazoles, -4H-oxazines, or tetrahydro-3H-thiazepines.
