134415-17-1Relevant articles and documents
One-step syntheses of substituted 2-pyrrolidinones and 3-pyrrolidinones from α,β-unsaturated diazoketones and amines. Application in the synthesis of barmumycin
Dias, Rafael M.P.,Momo, Patrícia B.,Burtoloso, Antonio C.B.
, p. 3720 - 3729 (2017/06/13)
A simple and one-pot way to prepare substituted 2- and 3-pyrrolidinones is described. The method uses unsaturated diazoketones (obtained from aldeydes in a single step) and amines, and provide an easy access to these important classes of nitrogen heterocycles. Furthermore, application of this methodology to the synthesis of the natural product barmumycin is achieved in 3 steps from these diazoketones.
Fast, acid-free, and selective lactamization of lactones in ionic liquids
Orrling, Kristina M.,Wu, Xiongyu,Russo, Francesco,Larhed, Mats
supporting information; experimental part, p. 8627 - 8630 (2009/04/11)
(Chemical Equation Presented) A fast and acid-free one-pot 0.2-30 mmol microwave methodology for direct ionic liquid-mediated preparation of lactams from lactones and primary amines has been developed. The protocol was investigated with a wide range of primary amines and a handful of lactones, including substrates with acid-sensitive substituents. Both γ-lactams and δ-lactams were, despite the complete absence of a Bronsted acid, obtained in useful to excellent yields after only 35 min of microwave processing.
