29179-33-7Relevant academic research and scientific papers
HISTONE DEACETYLASE INHIBITORS BASED ON ALPHACHALCOGENMETHYLCARBONYL COMPOUNDS
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Page column 21-22, (2008/06/13)
Histone deacetylase is a metallo-enzyme with zinc at the active site. Compounds having a zinc-binding moiety, for example, an alpha-chalcogenmethylcarbonyl group, such as an alpha-ketothio group, can inhibit histone deacetylase. Histone deacetylase inhibition can repress gene expression, including expression of genes related to tumor suppression. Accordingly, inhibition of histone deacetylase can provide an alternate route for treating cancer, hematological disorders, e.g., hemoglobinopathies, autosomal dominant disorders, e.g. spinal muscular atrophy and Huntington’s disease, genetic related metabolic disorders, e.g., cystic fibrosis and adrenoleukodystrophy, or for stimulating hematopoietic cells ex vivo.
Palladium-Catalyzed Syntheses of Conjugated Trienes
Kasahara, Akira,Izumi, Taeko,Kudou, Naoto
, p. 704 - 705 (2007/10/02)
Conjugated trienes 3 and 5 have been prepared by the palladium-catalyzed reaction of alkenes 2 with fumaryl chloride (1) and (E)-5-phenyl-2,4-pentadienoyl chloride (4), respectively, in the presence of N-ethylmorpholine.
A FACILE SYNTHESIS OF ο-SUBSTITUTED CONJUGATED POLYENONES VIA ARSONIUM SALT AND ITS APPLICATION TOWARDS THE SYNTHESIS OF NAVENONE A
Shi, Lilan,Xia, Wenjuan,Yang, Jianhua,Wen, Xueging,Huang, Y. Z.
, p. 2155 - 2158 (2007/10/02)
In the presence of K2CO3, a variety of aldehydes condensed with the arsonium bromide 8 at 0-3 deg C to give exclusively ο-substituted polyenones 1 in good yields, and the synthesis of navenone A was achieved by this procedure.
