29246-24-0Relevant academic research and scientific papers
Highly antiproliferative neutral Ru(ii)-arene phosphine complexes
Chotard, Florian,Dondaine, Lucile,Balan, Cédric,Betta?eb, Ali,Paul, Catherine,Le Gendre, Pierre,Bodio, Ewen
, p. 8105 - 8112 (2018)
Six ruthenium(ii)- and four gold(i)-phosphine based complexes were synthesized and fully characterized. Some of them displayed strong antiproliferative properties for several types of cancer including colon, breast, and lung. Notably, two of the Ru(ii) complexes displayed an IC50 of around 2 μM, which is exceptional for these types of complexes. The dramatic impact of the nature of the arene coordinated on the ruthenium center was clearly evidenced.
3-tert-Butyl-Substituted Cyclohexa-1,4-dienes as Isobutane Equivalents in the B(C6F5)3-Catalyzed Transfer Hydro-tert-Butylation of Alkenes
Keess, Sebastian,Oestreich, Martin
supporting information, p. 5925 - 5928 (2017/05/05)
Cyclohexa-1,4-dienes with a tert-butyl group at C3 are shown to function as isobutane equivalents when activated by the strong boron Lewis acid tris(pentafluorophenyl)borane. The hitherto unprecedented transfer hydro-tert-butylation from one unsaturated hydrocarbon to another is achieved with 1,1-diarylalkenes as substrates, thereby presenting itself as a new way of incorporating tertiary alkyl groups into carbon frameworks. Transient carbocation intermediates give rise to competing reaction pathways that could not be fully suppressed.
An unexpected Prins desymmetrisation reaction driven by silyl migration
Butters, Michael,Elliott, Mark C,Hill-Cousins, Joseph T.
experimental part, p. 113 - 125 (2012/10/08)
Prins desymmetrisation reactions of cyclohexa-1,4-diene derivatives have been investigated as a route to the core of the cladiellin diterpenes. During the course of this work, we observed the formation of a partially-reduced benzofuran 18, which is clearl
Metal-Ammonia Ring Reduction of Aromatic Carboxylic Acid Esters
Rabideau, Peter W.,Wetzel, Donna M.,Young, Michael D.
, p. 1544 - 1549 (2007/10/02)
Although esters are often reduced to alcohols with metal-ammonia solutions, it has been found that aromatic carbocyclic acid esters can be reduced efficiently to the corresponding dihydro aromatics when 1.25 equiv of water is present before metal addition.The general effect of the presence of water (before metal addition) upon metal-ammonia reduction of polycyclics was tested with anthracene (0.5g), which was reduced to 9,10-dihydroanthracene (97percent yield) in the presence of 3.5g of water.Polynuclear aromatic esters are reduced smoothly by this technique, but in the absence of water, alkyl 9-anthroates gave a dimer assigned as axial/axial on the basis of nuclear Overhauser enhancements.Possible mechanistic pathways for dimer formation were investigated by the addition of 9,10-dihydroanthracene monoanion as well as anthracene dianion to ammonia/THF solutions of ethyl anthroate.This led to dimer and trimer formation, respectively.The structures of these compounds are discussed in light of their carbon and proton NMR spectra.
Metal-ammonia reduction: the ring reduction of aromatic carboxylic esters
Rabideau, Peter W.,Huser, Diane L.,Nyikos, Steven J.
, p. 1401 - 1404 (2007/10/02)
Aryl benzoates are reduced to 1,4-dihydroaromatics with Na/NH3 in the presence of water.
