29246-55-7

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 67-64-1 acetone 
• 34764-77-7 methyl 3-bromo-1-propenyl ketone 
• 113388-28-6 ((E)-4-Oxo-pent-2-enyl)-triphenyl-arsonium; bromide 
• 100-52-7 benzaldehyde 
• 4173-44-8 (E,E)-6-phenyl-3,5-hexadien-2-one 

Downstream Products

• 14171-89-2 1-phenyl-5-hexanone 
• 1353719-46-6 (S)-5-methyl-5-((R,E)-5-oxo-1-phenylhex-1-en-3-yl)-2-phenyloxazol-4(5H)-one 
• 33599-88-1 (E)-6-phenylhex-5-en-2-one 
• 1408280-77-2 (E)-dimethyl 4-methyl-6-styrylisophthalate 
• 1293997-44-0 (S)-tert-butyl 2-oxo-5-((S,E)-5-oxo-1-phenylhex-1-en-3-yl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 1209466-54-5 (E)-4-(nitromethyl)-6-phenylhex-5-en-2-one 
• 1165944-75-1 (S)-(E)-4-(nitromethyl)-6-phenyl-5-hexen-2-one 
• 78925-42-5 1-(3-hydroxy-4-methoxyphenyl)-7-phenyl-3-heptanone 

Relevant academic research and scientific papers

Synthesis of Polysubstituted Pyridines via a One-Pot Metal-Free Strategy

An efficient strategy for the one-pot synthesis of polysubstituted pyridines via a cascade reaction from aldehydes, phosphorus ylides, and propargyl azide is reported. The reaction sequence involves a Wittig reaction, a Staudinger reaction, an aza-Wittig reaction, a 6π-3-azatriene electrocyclization, and a 1,3-H shift. This protocol provides quick access to the polysubstituted pyridines from readily available substrates in good to excellent yields.

A FACILE SYNTHESIS OF ο-SUBSTITUTED CONJUGATED POLYENONES VIA ARSONIUM SALT AND ITS APPLICATION TOWARDS THE SYNTHESIS OF NAVENONE A

In the presence of K2CO3, a variety of aldehydes condensed with the arsonium bromide 8 at 0-3 deg C to give exclusively ο-substituted polyenones 1 in good yields, and the synthesis of navenone A was achieved by this procedure.

Synthesis of diarylheptanoids and assessment of their pungency

With the aim of correlating pungency with substituent groups on one benzene ring, various analogues of yakuchinones were synthesized by means of the Claisen-Schmidt reaction. Their pungencies were assessed by direct comparison of the threshold concentrations obtained in taste experiments. The presence of a phenolic hydroxyl group was indispensable for high pungency, while that of a 1,2-double bond of the heptanone part tended to decrease the pungency.