29268-18-6

Usage

Uses

Used in Pharmaceutical Industry:
(2S)-2-[(PHENYLSULFONYL)AMINO]PROPANOIC ACID is used as a drug candidate for the development of therapeutic agents targeting specific enzymes or receptors. Its potential applications include the treatment of various diseases, such as cancer and neurological disorders.
Used in Medicinal Chemistry:
(2S)-2-[(PHENYLSULFONYL)AMINO]PROPANOIC ACID is used as a chemical compound in medicinal chemistry for the synthesis of new drugs and the study of its biological activity and mechanism of action.

Upstream product

• 56-41-7 L-alanin 
• 98-09-9 benzenesulfonyl chloride 
• 25191-17-7 L-Ala 

Downstream Products

• 79821-75-3 (S)-2-<(phenylsulfonyl)amino>-1-phenyl-1-propanone 
• 29268-20-0 N-(phenylsulfonyl)-L-alanyl chloride 
• 59724-68-4 N-phenylsulfonyl-L-alanine methyl ester 
• 543725-59-3 N-(1-hydrazinocarbonyl-ethyl)-benzenesulfonamide 
• 543725-67-3 N-[1-methyl-2-(3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)-2-oxo-ethyl]-benzenesulfonamide 
• 79821-84-4 (S)-N-(benzenesulfonyl)amphetamine 
• 91111-08-9 N-((S)-2-Hydroxy-1-methyl-2-phenyl-ethyl)-benzenesulfonamide 

Relevant academic research and scientific papers

Design, synthesis, molecular docking, antimicrobial, and antioxidant activities of new phenylsulfamoyl carboxylic acids of pharmacological interest

The research explores the facile synthesis of some new phenylsulfamoyl carboxylic acids, their molecular docking, antimicrobial, and antioxidant activities. The procedure involved the mild reaction of amino acids with benzenesulfonyl chloride in a medium

New chiral aminoamidoximes: Syntheses and investigation of heterocyclic compounds

New chiral aminoamidoximes were prepared from (L)-proline, (L)-alanine, and (L)-isoleucine by treatment of the corresponding aminonitriles with hydroxylamine in the presence of triethylamine. The intramolecular cyclization with α-bromoacid chlorides and aldehydes was investigated to give new 1,2,4-oxadiazin-6-ones and 1,2,4-oxadiazoles, respectively. These compounds were likely to undergo an intermolecular cyclization through oxygen and nitrogen. However, intramolecular cyclization through two nitrogens did not occur even after changing reaction conditions. Taylor & Francis Group, LLC.

Design, synthesis and in vitro biochemical activity of novel amino acid sulfonohydrazide inhibitors of MurC

Mur ligases are essential enzymes involved in the cytoplasmic steps of peptidoglycan synthesis which remain attractive, yet unexploited targets. In order to develop new antibacterial agents, we have designed a series of new MurC and MurD inhibitors bearin

Synthesis, characterization and antifungal activities of some benzenesulphonylamino acid derivatives

Condensation of benzenesulphonyl chloride (1) with a series of amino acids afforded benzenesulphonylamino acids (2a-d). Esterification of the derivatives (2a-d) in methanol gave the corresponding benzensulphonylamino acid methylesters (3a-d), which conden

Thiadiazines and their use as inhibitors of metalloproteinases

The present invention provides novel thiadiazines represented by formula (I) which are useful as inhibitors of metalloproteinases. Also disclosed are pharmaceutical compositions and methods of treating disorders associated with increased activity of metal

Structure-based design and synthesis of potent matrix metalloproteinase inhibitors derived from a 6H-1,3,4-thiadiazine scaffold

We describe a new generation of heterocyclic nonpeptide matrix metalloproteinase (MMP) inhibitors derived from a 6H-1,3,4-thiadiazine scaffold. A screening effort was utilized to identify some chiral 6-methyl-1,3,4-thiadiazines that are weak inhibitors of

α-Amino Acids as Chiral Educts for Asymmetric Products. The Synthesis of α'-Amino-α,β-ynones

α-Amino acid isoxazolidides have been developed as educts for the preparation of optically pure α'-amino-α,β-ynones.The α-amino acids were first N-protected as their ethoxycarbonyl, tert-butoxycarbonyl, or phenylsulfonyl derivatives.The isoxazolidides then were formed by the simple, high yield acylation of isoxazolidine by in situ generated α-amino acid isobutyl carbonic anhydrides.Individual isoxazolidides of L-α-N-substituted alanine, phenylalanine, and methionine, when treated with lithium acetylide, lithium (trimethylsilyl)acetylide, or 1-hexynyllithium, gave high yields of the corresponding optically pure α,β-acetylenic ketones.

α-Amino Acids as Chiral Educts for Asymmetric Products. Amino Acylation with N-Acylamino Acids

α-N-Acylamino acids have been developed as useful reagents for the preparation of optically pure α-aminoalkylaryl ketones.Protection of the amino group as either the ethoxycarbonyl or benzenesulfonyl derivative allows alanine to serve as an effective educt for the chirally specific synthesis of a variety of structures containing the phenylethylamine backbone.Benzene undergoes Friedel-Crafts acylation with the N-acylalanine acid chloride.Catalyst complexation with oxagenated aromatics, however, prohibits acylation of aryl ethers.An arylmetallo reaction scheme overcomes this problem and also affords regiospecificity not attainable in conventional acylations.As examples, optically pure ephedrines and amphetamines were directly synthesized without recourse to resolution since the chirality of the amino acid educt was entirely conserved throughout the process.

Method for controlling the growth of plants

A method for controlling the growth of plants, characterized by applying a plant growth regulator containing as active ingredient a benzenesulfonamide derivative represented by the general formula, STR1 wherein X is a halogen atom, an alkyl group having 1