29268-33-5

Usage

Uses

Used in Pharmaceutical Industry:
(2-Phenylquinolin-4-yl)methanol is used as a pharmaceutical compound for its anti-inflammatory properties, helping to reduce inflammation and alleviate symptoms associated with various inflammatory conditions.
(2-Phenylquinolin-4-yl)methanol is used as an anti-cancer agent, targeting and inhibiting the growth of cancer cells, making it a potential candidate for the development of new cancer treatments.
(2-Phenylquinolin-4-yl)methanol is used as an anti-microbial agent, exhibiting the ability to combat microbial infections, which could lead to the creation of new antimicrobial drugs.
These applications highlight the versatility and potential of (2-Phenylquinolin-4-yl)methanol in addressing a range of health issues, from inflammation to cancer and microbial infections, underscoring its importance in ongoing pharmaceutical research and development.

Upstream product

• 117839-38-0 2-phenyl-4-quinolinecarboxaldehyde 
• 4546-48-9 methyl 2-phenylquinoline-4-carboxylate 
• 100-52-7 benzaldehyde 
• 107-19-7 propargyl alcohol 
• 62-53-3 aniline 
• 67-56-1 methanol 
• 612-96-4 2-Phenylquinoline 
• 132-60-5 cinchophen 

Downstream Products

• 117839-38-0 2-phenyl-4-quinolinecarboxaldehyde 
• 612-96-4 2-Phenylquinoline 
• 4789-76-8 4-methyl-2-phenylquinoline 

Relevant academic research and scientific papers

Cu(I)-catalyzed three component coupling protocol for the synthesis of quinoline derivatives

Synthesis of 2,4-disubstituted quinolines has been achieved in a one-pot reaction from an aryl amine, an aldehyde and a terminal alkyne using CuCl (30 mol%) as a catalyst.

Hydroxymethylation of quinolinesviairon promoted oxidative C-H functionalization: synthesis of arsindoline-A and its derivatives

Herein, we report a mild and efficient hydroxymethylation of quinolinesviaan iron promoted cross-dehydrogenative coupling reaction under external acid free conditions. Various hydroxyalkyl substituted quinolines were achieved in excellent yields with well tolerated functional groups. Importantly, a few of the hydroxylmethylated quinolines were further transformed into respective aldehydes, and were successfully utilized for the synthesis of alkaloid arsindoline-A and its derivatives.

Scalable Photoelectrochemical Dehydrogenative Cross-Coupling of Heteroarenes with Aliphatic C?H Bonds

Heteroarenes are structural motifs found in many bioactive compounds and functional materials. Dehydrogenative cross-coupling of heteroarenes with aliphatic C?H bonds provides straightforward access to functionalized heteroarenes from readily available materials. Established methods employ stoichiometric chemical oxidants under conditions of heating or light irradiation. By merging electrochemistry and photochemistry, we have achieved efficient photoelectrochemical dehydrogenative cross-coupling of heteroarenes and C(sp3)?H donors through H2 evolution, without the addition of metal catalysts or chemical oxidants. Mechanistically, the C(sp3)?H donor is converted to a nucleophilic carbon radical through H-atom transfer with chlorine atom, which is produced by light irradiation of anodically generated Cl2 from Cl?. The carbon radical then undergoes radical substitution to the heteroarene to afford alkylated heteroarene products.

QUINOLINES DERIVATIVES AS NOVEL ANTICANCER AGENTS

The invention provides quinoline derivatives, their manufacture, pharmaceutical compositions containing them, and their use as medicaments. The active compounds of the present invention are useful for the treatment of proliferative neoplastic and nonneoplastic diseases.

Studies on novel 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones as potential TACE inhibitors: Design, synthesis, molecular modeling, and preliminary biological evaluation

Compounds belonging to the class of 2-imidazolidinones and tetrahydropyrimidin-2(1H)-ones were synthesized and evaluated for their TACE inhibitory activity. Most of the compounds showed very good TACE inhibitory activity. Docking study clearly indicates importance of the P1′ group of the inhibitor for the TACE inhibitory activity. This work proves that these two classes of molecules could be used as potential leads for the development of TACE inhibitors.

Quinoline derivatives and medicinal use thereof

A quinoline derivative represented by the following formula (1): allows PPARα or γ which is an intranuclear transcription factor, to function strongly and is low in toxicity. By using this compound as an active ingredient, there can be provided a preventive or therapeutic agent for various diseases related to PPARα or γ.