2928-17-8

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-Fluoro-phenyl)-2-methyl-propan-2-ol is used as a building block for the synthesis of various pharmaceutical products. Its unique structure and properties contribute to the development of new drugs and medicinal compounds, enhancing their efficacy and selectivity.
Used in Agrochemical Industry:
In the agrochemical sector, 1-(4-Fluoro-phenyl)-2-methyl-propan-2-ol is utilized as a key component in the creation of agrochemical products. Its incorporation aids in the formulation of effective pesticides, herbicides, and other agricultural chemicals, promoting crop protection and yield enhancement.
Used as a Reagent in Organic Chemistry:
1-(4-Fluoro-phenyl)-2-methyl-propan-2-ol serves as a reagent in various organic chemistry reactions. Its ability to participate in a range of chemical processes, such as esterification, acylation, and substitution reactions, makes it a valuable tool for synthesizing complex organic molecules and compounds.
Used as a Chiral Auxiliary in Asymmetric Synthesis:
Recognized for its properties as a chiral auxiliary, 1-(4-Fluoro-phenyl)-2-methyl-propan-2-ol is employed in the asymmetric synthesis of certain compounds. Its use in this context facilitates the production of enantiomerically pure compounds, which is crucial for the development of pharmaceuticals with improved efficacy and reduced side effects.

InChI:InChI=1/C10H13FO/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6,12H,7H2,1-2H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 459-03-0 4-fluorophenyl acetone 
• 130387-74-5 4-fluorophenylmagnesium chloride 
• 67-64-1 acetone 
• 459-46-1 4-Fluorobenzyl bromide 
• 75-16-1 methylmagnesium bromide 
• 352-11-4 1-chloromethyl-4-fluorobenzene 

Downstream Products

• 706-24-1 1-(β-chloro-isobutyl)-4-fluoro-benzene 
• 702-09-0 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene 
• 142393-68-8 2-Amino-propionic acid 2-(4-fluoro-phenyl)-1,1-dimethyl-ethyl ester 
• 1240520-49-3 4-(2,2-dimethyl-4-pentenyl)-1-fluorobenzene 
• 1240520-37-9 C₁₀H₁₂BrF 
• 1240520-40-4 4-(2,2-dimethyl-3-phenylpropyl)-1-fluorobenzene 

Relevant academic research and scientific papers

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

The first transition-metal-free, site-specific umpolung trifluoromethylthiolation of tertiary alkyl ethers has been developed, achieving the challenging tertiary C(sp3)–SCF3 coupling under redox-neutral conditions. The synergism of organophotocatalyst 4CzIPN and BINOL-based phosphorothiols can site-selectively cleave tertiary sp3 C(sp3)–O ether bonds in complex molecules initiated by a polarity-matching hydrogen-atom-transfer (HAT) event. The incorporation of several competing benzylic and methine C(sp3)?H bonds in alkyl ethers has little influence on the regioselectivity. Selective difluoromethylthiolation of C?O bonds has also been achieved. This represents not only an important step forward in trifluoromethylthiolation but also a promising means for site-selective C?O bond functionalization of unsymmetrical tertiary alkyl ethers.

1 — (4 — Fluorophenyl) — 2 — methyl — 2 — propylamine synthetic method

The invention relates to the synthesis of organic substances, in particular to a synthetic method of 1-(4-fluorophenyl)-2-methyl-2-propylamine, comprising the following steps of: firstly, synthesizing 1,1-dimethyl parafluorobenzoic alcohol: adding magnesium powder dried at 95 DEG C by heating into an organic solution of parafluorobenzoic chloride to react, then dropping acetone to react, and then adding 5-20 percent of diluted hydrochloric acid solution, depositing a lemon-yellow organic phase and distilling off the organic solution by a rotary atmometer; secondly, synthesizing parafluoro acylamide: adding acetonitrile and acid liquor which are used as raw materials into the 1,1-dimethyl parafluorobenzoic alcohol to react, then distilling off the acetonitrile, adding a reaction liquid into water, then adding sodium hydroxide for neutralizing until the pH value reaches 6-7, separating out white solid particles, filtering and washing; and thirdly, synthesizing the 1-(4-fluorophenyl)-2-methyl-2-propylamine: adding the parafluoro acylamide and potassium hydroxide solution into a high pressure kettle, replacing with nitrogen, and then depositing a lemon-yellow oil layer to obtain a crude product. The invention has reasonable synthesis route, mild reaction, easy operation, low cost of raw materials, high product yield and high purity.

Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligands

A novel Pd(II)-catalyzed ortho-C-H olefination protocol has been developed using spatially remote, unprotected tertiary, secondary, and primary alcohols as the directing groups. Mono-N-protected amino acid ligands were found to promote the reaction, and an array of olefin coupling partners could be used. When electron-deficient alkenes were used, the resulting olefinated intermediates underwent subsequent Pd(II)-catalyzed oxidative intramolecular cyclization to give the corresponding pyran products, which could be converted into ortho-alkylated alcohols under hydrogenolysis conditions. The mechanistic details of the oxidative cyclization step are discussed and situated in the context of the overall catalytic cycle.