2928-17-8

Basic information

• Product Name: 1-(4-FLUORO-PHENYL)-2-METHYL-PROPAN-2-OL
• Synonyms: 1-(4-FLUORO-PHENYL)-2-METHYL-PROPAN-2-OL;2-(4-FLUOROPHENYL)-1,1-DIMETHYLETHANOL;1,1-Dimethyl-2-(4-fluorophenyl)ethan-1-ol
• CAS NO: 2928-17-8
• Molecular Formula: C₁₀H₁₃FO
• Molecular Weight: 168.21
• Mol File: 2928-17-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 235.3 °C at 760 mmHg
• Flash Point: 117.9 °C
• Appearance: /
• Density: 1.071 g/cm³
• Vapor Pressure: 0.0278mmHg at 25°C
• Refractive Index: 1.504
• CAS DataBase Reference: 1-(4-FLUORO-PHENYL)-2-METHYL-PROPAN-2-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-FLUORO-PHENYL)-2-METHYL-PROPAN-2-OL(2928-17-8)
• EPA Substance Registry System: 1-(4-FLUORO-PHENYL)-2-METHYL-PROPAN-2-OL(2928-17-8)

Safety Data

• Hazardous Substances Data: 2928-17-8(Hazardous Substances Data)

Usage

General Description

1-(4-Fluoro-phenyl)-2-methyl-propan-2-ol is an organic compound with a chemical formula of C10H13FO. It is a colorless liquid with a molecular weight of 166.21 g/mol. 1-(4-FLUORO-PHENYL)-2-METHYL-PROPAN-2-OL is used as a building block in the synthesis of various pharmaceutical and agrochemical products. It is also used as a reagent in organic chemistry reactions. 1-(4-Fluoro-phenyl)-2-methyl-propan-2-ol is known for its properties as a chiral auxiliary, making it useful in the asymmetric synthesis of certain compounds. Overall, this chemical has applications in both the pharmaceutical and chemical industries.

InChI:InChI=1/C10H13FO/c1-10(2,12)7-8-3-5-9(11)6-4-8/h3-6,12H,7H2,1-2H3

Upstream product

• 917-64-6 methyl magnesium iodide 
• 459-03-0 4-fluorophenyl acetone 
• 130387-74-5 4-fluorophenylmagnesium chloride 
• 67-64-1 acetone 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 75-16-1 methylmagnesium bromide 
• 459-46-1 4-Fluorobenzyl bromide 

Downstream Products

• 1240520-40-4 4-(2,2-dimethyl-3-phenylpropyl)-1-fluorobenzene 
• 1240520-37-9 C₁₀H₁₂BrF 
• 1240520-49-3 4-(2,2-dimethyl-4-pentenyl)-1-fluorobenzene 
• 142393-68-8 2-Amino-propionic acid 2-(4-fluoro-phenyl)-1,1-dimethyl-ethyl ester 
• 702-09-0 1-fluoro-4-(2-methylprop-1-en-1-yl)benzene 
• 706-24-1 1-(β-chloro-isobutyl)-4-fluoro-benzene 

Relevant articles and documents

Synergistic Catalysis for the Umpolung Trifluoromethylthiolation of Tertiary Ethers

The first transition-metal-free, site-specific umpolung trifluoromethylthiolation of tertiary alkyl ethers has been developed, achieving the challenging tertiary C(sp3)–SCF3 coupling under redox-neutral conditions. The synergism of organophotocatalyst 4CzIPN and BINOL-based phosphorothiols can site-selectively cleave tertiary sp3 C(sp3)–O ether bonds in complex molecules initiated by a polarity-matching hydrogen-atom-transfer (HAT) event. The incorporation of several competing benzylic and methine C(sp3)?H bonds in alkyl ethers has little influence on the regioselectivity. Selective difluoromethylthiolation of C?O bonds has also been achieved. This represents not only an important step forward in trifluoromethylthiolation but also a promising means for site-selective C?O bond functionalization of unsymmetrical tertiary alkyl ethers.

Pd(II)-catalyzed hydroxyl-directed C-H olefination enabled by monoprotected amino acid ligands

A novel Pd(II)-catalyzed ortho-C-H olefination protocol has been developed using spatially remote, unprotected tertiary, secondary, and primary alcohols as the directing groups. Mono-N-protected amino acid ligands were found to promote the reaction, and an array of olefin coupling partners could be used. When electron-deficient alkenes were used, the resulting olefinated intermediates underwent subsequent Pd(II)-catalyzed oxidative intramolecular cyclization to give the corresponding pyran products, which could be converted into ortho-alkylated alcohols under hydrogenolysis conditions. The mechanistic details of the oxidative cyclization step are discussed and situated in the context of the overall catalytic cycle.