292850-52-3

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 5689-71-4 2-(4-methoxy-phenyl)-[1,3]dioxane 
• 201667-72-3 methyl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate 

Downstream Products

• 474827-11-7 (+)-(2aS,3R,6aS,6bS)-hexahydro-3-{2-[(4-methoxyphenyl)methoxy]ethyl}-2H-1,4-dioxa-4a-azacyclopenta[cd]pentalen-2-one 
• 474827-09-3 (4S)-2,3-dicyanohexahydropyrrolo[1,2-b]isoxazol-4-yl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate 
• 292850-58-9 (3aR,4R)-5-(4-methoxybenzyloxy)-pent-2-enoic acid 2-phenyl-2,3,3a,4,5,6-hexahydro-pyrrolo[1,2-b]isoxazol-4-yl ester 
• 474827-07-1 ethyl (3aR,4S)-hexahydro-4-{[(2E)-5-(4-methoxybenzyloxy)-1-oxo-2-pentenyl]oxy}pyrrolo[1,2-b]isoxazole-2-carboxylate 
• 292850-60-3 (-)-(2aR,3S,6aR,6bR)-hexahydro-3-{2-[(4-methoxyphenyl)methoxy]ethyl}-2H-1,4-dioxa-4a-azacyclopenta[cd]pentalen-2-one 
• 474827-06-0 (3aR,4S)-hexahydro-2-phenylpyrrolo[1,2-b]isoxazol-4-yl (2E)-5-(4-methoxybenzyloxy)-2-pentenoate 

Relevant academic research and scientific papers

Stereodivergent approach to enantiopure hydroxyindolizidines through 1,3-dipolar cycloaddition of 3-hydroxypyrroline N-oxide derivatives

The (3S)-3-alkoxypyrroline N-oxides 7 and 27 were easily prepared from 1-malic acid and used as starting materials for enantiospecific syntheses of stereo differentiated polyhydro-xyindolizidines. Selection of the appropriate modality (inter or intramolec

Stereoselective approach to hydroxyindolizidines: Protection/deprotection of the nitrone functionality via cycloaddition/retrocycloaddition

(equation presented) The enantiomerically pure indolizidine (-)-21 has been synthesized starting from L-malic acid. The key intermediate 20 has been assembled through an intramolecular 1,3-dipolar cycloaddition of a nitrone generated in situ by retrocyclo