29339-44-4

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 6267-39-6 3-ethoxy-5,5-dimethyl-2-cyclohexen-1-one 
• 141-79-7 4-methyl-pent-3-en-2-one 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 95849-63-1 1-(4-(butyltellanyl)phenyl)ethan-1-one 
• 849595-89-7 3-(butyltellanyl)-5,5-dimethyl-cyclohex-2-enone 
• 4694-17-1 5,5-dimethlycyclohex-2-en-1-one 
• 126-81-8 dimedone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 77708-65-7 5,5-dimethyl-3-oxocyclohex-1-en-1-yl 4-methylbenzenesulfonate 
• 15466-96-3 3-isobutoxy-5,5-dimethylcyclohex-2-en-1-one 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 77729-48-7 3-(4-Methoxy-phenyl)-5,5-dimethyl-cyclohex-2-enone oxime 
• 77729-36-3 6-(4'-methoxyphenyl)-4,4-dimethyl-2,3,4,5-tetrahydro-1H-azepin-2-one 
• 77729-31-8 4-(4'-methoxyphenyl)-6,6-dimethyl-2,5,6,7-tetrahydro-1H-azepin-2-one 
• 77729-41-0 4-(4'-methoxyphenyl)-6,6-dimethylhexahydroazepin-2-one 
• 77729-50-1 3-(4'-methoxyphenyl)-5,5-dimethyl-cyclohex-2-en-1-one oxime tosylate 
• 37779-16-1 3-p-Methoxyphenyl-5,5-dimethyl-2-cyclohexen-1-ol 

Relevant academic research and scientific papers

Total synthesis of (+)-ar -macrocarpene

This report features the first catalytic asymmetric total synthesis of a sesquiterpene, (+)-ar-macrocarpene (1), in 7 steps with 42.1% overall yields from commercially available inexpensive 5,5-dimethylcyclohexane 1,3-dione. This strategy relies on a key [3,3]-sigmatropic rearrangement effecting reductive transposition through allylic diazene rearrangement (ADR) in a single step from intermediate allylic alcohol (+)-12 under the Mitsunobu reaction conditions with o-nitrobenzenesulfonyl hydrazide (o-NBSH). Enantioselective reduction of α-bromo vinylogous ester 16 under the Corey-Bakshi-Shibata reduction conditions forges the required stereocenter in the allylic alcohol (+)-12 in a highly enantioenriched manner (95% ee).

ANTICONVULSANT COMPOUNDS

The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain.

Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones

Phosphonium salt-activated, Pd-catalyzed Suzuki-Miyaura and Sonogashira cross-coupling reactions of cyclic 1,3-diones in the synthesis of β-substituted cyclic enones are described. These transformations exhibit good isolated yield and high generality with respect to both substrates and coupling partners. Extension of the substrate scope to cyclic 1,3-dione equivalents, such as 2-cyanocyclohexanone (4), is also briefly examined.

Synthesis of 2-Arylpyridopyrimidinones, 6-Aryluracils, and Tri- and Tetrasubstituted Conjugated Alkenes via Pd-Catalyzed Enolic C-O Bond Activation-Arylation

A new and efficient approach for the synthesis of biologically important 2-aryl-4H-pyrido[1,2-a]pyrimidin-4-ones and 6-aryluracils via previously unknown Pd-catalyzed enolic C-OH activation-arylation of pyridopyrimidin-2,4-diones and barbituric acids, res

Ligand- and base-free Pd(II)-catalyzed controlled switching between oxidative heck and conjugate addition reactions

A simple change of solvent allows controlled and efficient switching between oxidative Heck and conjugate addition reactions on cyclic Michael acceptor substrates, catalyzed by a cationic Pd(II) catalyst system. Both reactions are ligand- and base-free and tolerant of air and moisture, and the controlled switching sheds light on some of the factors which favor one reaction over the other.

The coupling of butylvinyltellurides with organometallic reagents catalysed by nickel complexes

Vinylic tellurides couple efficiently with sp, sp2 and sp3 hybridised organometallic compounds (Li, MgX and Zn species) in the presence of dichloro-bis(triphenylphosphine)nickel(II) as catalyst.