2937-99-7

Basic information

• Product Name: 5-Benzylamino-1-pentanol
• Synonyms: 5-Benzylamino-1-pentanol;N-(5-Hydroxyamyl)benzylamine N-(5-Hydroxypentyl)benzylamine
• CAS NO: 2937-99-7
• Molecular Formula: C₁₂H₁₉NO
• Molecular Weight: 193.28536
• Mol File: 2937-99-7.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 168°C/6mmHg(lit.)
• Flash Point: 100.753°C
• Appearance: /
• Density: 0.993g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.5270-1.5310
• CAS DataBase Reference: 5-Benzylamino-1-pentanol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Benzylamino-1-pentanol(2937-99-7)
• EPA Substance Registry System: 5-Benzylamino-1-pentanol(2937-99-7)

Safety Data

• Hazardous Substances Data: 2937-99-7(Hazardous Substances Data)

Usage

General Description

5-Benzylamino-1-pentanol is a chemical compound that belongs to the class of amino alcohols. It is a primary amine with a benzyl group attached to the amino group and a hydroxyl group attached to the carbon chain. 5-Benzylamino-1-pentanol has potential applications in organic synthesis as a chiral building block and in medicinal chemistry as a precursor for the synthesis of pharmaceuticals. Its unique structural features make it a valuable tool in the development of new molecules with biological activity. Additionally, 5-Benzylamino-1-pentanol may also have potential uses in the formulation of specialty chemicals and as a reagent in chemical research.

InChI:InChI=1/C12H19NO/c14-10-6-2-5-9-13-11-12-7-3-1-4-8-12/h1,3-4,7-8,13-14H,2,5-6,9-11H2

Upstream product

• 110-87-2 3,4-dihydro-2H-pyran 
• 100-46-9 benzylamine 
• 208244-48-8 5-{[1-Phenyl-meth-(E)-ylidene]-amino}-pentan-1-ol 
• 2508-29-4 5-hydroxypentylamine 
• 100-52-7 benzaldehyde 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 42856-59-7 5-hydroxy-N-(phenylmethyl)-pentanamide 
• 111-24-0 1,5-dibromo-pentane 
• 5259-98-3 5-chloropentan-1-ol 

Downstream Products

• 213771-60-9 tert-Butyl N-benzyl-5-hydroxypentylcarbamate 
• 357277-83-9 [(4-benzyl-2-{1-[benzyl-(5-hydroxy-pentyl)-amino]-heptyl}-oxazol-5-yl)-methyl-amino]-acetic acid methyl ester 
• 1426441-01-1 methyl 3-(4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)phenyl)propanoate 
• 102666-89-7 N-benzyl-5-(1-benzylpiperidin-2-yl)-1,2,3,4-tetrahydropyridine 
• 694-54-2 tetrahydro-2H-2-pyranol 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 60460-73-3 1-benzyl-1,2,3,4-tetrahydropyridine 
• 2905-56-8 N-Benzylpiperidine 
• 6295-81-4 N-benzylpiperidine hydrochloride 
• 1619229-63-8 C₁₆H₂₉NOSi 
• 196880-31-6 C₁₂H₁₈ClN 
• 1276114-07-8 N-benzyl-5-((2,3-dimethylbutan-2-yl)dimethylsilyloxy)pentan-1-amine 
• 1276114-28-3 C₃₆H₄₉NO₅Si 
• 1276114-12-5 4-((benzyl(5-hydroxypentyl)carbamoyloxy)methyl)benzyl benzoate 

Relevant articles and documents

Hapten design and monoclonal antibody to fluoroacetamide, a small and highly toxic chemical

Fluoroacetamide (FAM) is a small (77 Da) and highly toxic chemical, formerly used as a rodenticide and potentially as a poison by terrorists. Poisoning with FAM has occurred in humans, but few reliably rapid detection methods and antidotes have been reported. Therefore, producing a specific antibody to FAM is not only critical for the development of a fast diagnostic but also a potential treatment. However, achieving this goal is a great challenge, mainly due to the very low molecular weight of FAM. Here, we design two groups of FAM haptens for the first time, maximally exposing the fluorine or amino groups, with the aid of linear aliphatic or phenyl-contained spacer arms. Interestingly, whereas the hapten with fluorine at the far end of the hapten did not induce an antibody response to FAM, the hapten with an amino group at the far end and phenyl-contained spacer arm triggered a significantly specific antibody response. Finally, a monoclonal antibody (mAb) named 5D11 was successfully obtained with an IC50 value of 97 μg mL?1 and negligible cross-reactivities to the other nine functional and structural analogs.

The scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: Methodology and reactor design

Biphasic liquid/liquid reactions are commonplace, however their scale-up under super-heating conditions is not. Even more challenging efforts have to be expected in the case of a large scale continuous production process, which also includes the development at a lab scale, the selection and design of the continuous reaction equipment. However, by running chemistry above the boiling point of the solvent, the solvent selection can be widened to include green solvents and continuous processing guarantees a limited and safe footprint. Herein is reported a systematic methodology for the development and scale-up of a biphasic reaction under super-heating conditions, as well as the design of a continuous reactor column suitable for handling such conditions. Taking the alkylation of benzylamine with 1,5-dibromopentane as a model reaction, kinetic determination and fluid dynamic characterization of the biphasic media have been instrumental for a successful scale-up concept which was proven in a custom-made hastelloy reactor column.

Broadening the chemical scope of laccases: Selective deprotection of N-benzyl groups

Laccase from Trametes versicolor together with TEMPO has been found to be a very efficient system to deprotect N-benzylated primary amines, differing from previously described methods since it uses oxygen as a mild oxidant in aqueous medium. Chemoselective removal of the benzyl group was achieved with excellent yields when secondary amines and alcohol moieties were also present.