60460-73-3

Upstream product

• 40240-12-8 1-benzyl-1,2,3,6-tetrahydropyridine 
• 19774-49-3 1-phenyloctahydropyrido[1,2-c][1,3]oxazine 
• 100-52-7 benzaldehyde 
• 2508-29-4 5-hydroxypentylamine 
• 208244-48-8 5-{[1-Phenyl-meth-(E)-ylidene]-amino}-pentan-1-ol 
• 2937-99-7 N-benzyl-5-aminopentan-1-ol 
• 675-20-7 piperidin-2-one 
• 100-39-0 benzyl bromide 
• 4783-65-7 N-benzyl-2-piperidinone 

Downstream Products

• 2905-56-8 N-Benzylpiperidine 
• 57742-89-9 ethyl 1-benzyl-1,4,5,6-tetrahydropyridine-3-carboxylate 

Relevant academic research and scientific papers

C(sp3)-H dehydrogenation and C(sp2)-H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles

A novel and efficient synthesis of tetrahydropyridine (THP)-, dihydropyrrole (DHP)-, or tetrahydroazepine (THA)-3-carboxylates via cascade reactions of inactivated cyclic amines with CO and alcohols is presented. To our knowledge, this should be the first

Broadening the chemical scope of laccases: Selective deprotection of N-benzyl groups

Laccase from Trametes versicolor together with TEMPO has been found to be a very efficient system to deprotect N-benzylated primary amines, differing from previously described methods since it uses oxygen as a mild oxidant in aqueous medium. Chemoselective removal of the benzyl group was achieved with excellent yields when secondary amines and alcohol moieties were also present.

Pyrolysis of perhydro[1,2-c][1,3]oxazines: A green method of synthesizing 2,3-dehydropiperidine enamines

Heat pyrolysis of the oxazines formed from 2-piperidineethanol produced 2,3-dehydropiperidine enamines. The same results were observed when these oxazines were irradiated with microwaves. Various 2-substituted perhydrooxazines were synthesized by allowing 2-piperidineethanol or 2-piperidinemethanol to react with aldehydes or ketones.

Carbene reactions of α-oxacyclo- and α-azacyclo-N-aziridinylimines: Effect of heteroatom and ring size in the ring expansion reaction

Carbenes, generated from thermolysis of α-oxacyclo- and α-azacyclo-N-aziridinylimines in refluxing toluene, underwent ring expansions via insertion of alkyl carbenes into carbon-carbon bonds and intramolecular ammonium ylide formations, respectively. Ring expansion reaction of α-oxetanyl-N-aziridinylimines occurred via alkylidenecarbene intermediates, whereas thermal reaction of α-azetidinyl-N-aziridinylimines afforded α-aminoacetylene compounds via 1,2-H migration of alkylidenecarbene intermediates.