6295-81-4

Usage

Common Use

Reagent in organic synthesis and pharmaceutical research

Type

Hydrochloride salt of 1-benzylpiperidine

Structure

Substituted piperidine derivative

Applications

a. Starting material for the synthesis of various pharmaceutical agents
b. Preparation of other organic compounds

Safety Precautions

Handle with care and follow proper safety measures to avoid hazards

Storage

Store in a cool, dry place, away from heat and moisture

Stability

Stable under normal conditions, but sensitive to light and heat

Solubility

Soluble in water and most organic solvents

Physical Appearance

White to off-white crystalline solid

Melting Point

Approximately 200-210°C

Boiling Point

Not readily available, but expected to be high due to its crystalline nature

Purity

Typically available in high purity (>98%)

Hazardous Nature

Can be hazardous if not used and stored properly

Regulatory Information

Follow local and international regulations for handling and disposal of chemicals

Disposal

Dispose of in accordance with local and international guidelines for hazardous materials

Reactivity

Reacts with strong acids, bases, and oxidizing agents

Flammability

Not considered highly flammable, but proper precautions should be taken to avoid fire hazards

Toxicity

Potentially toxic if ingested, inhaled, or absorbed through the skin

First Aid Measures

In case of contact, immediately rinse affected area with plenty of water and seek medical attention if necessary

Upstream product

• 776-75-0 N-benzoylpiperidine 
• 110-89-4 piperidine 
• 59611-77-7 1-(chloro-phenyl-methylene)-piperidinium; chloride 
• 208244-48-8 5-{[1-Phenyl-meth-(E)-ylidene]-amino}-pentan-1-ol 
• 2508-29-4 5-hydroxypentylamine 
• 100-52-7 benzaldehyde 
• 2937-99-7 N-benzyl-5-aminopentan-1-ol 
• 196880-31-6 C₁₂H₁₈ClN 
• 6091-44-7 piperidine hydrochloride 
• 100-51-6 benzyl alcohol 
• 98-88-4 benzoyl chloride 
• 16156-59-5 phenyl methanesulfonate 
• 1268340-93-7 N-(trifluoroboratomethyl)piperidine internal salt 

Relevant academic research and scientific papers

Method for preparing amine compound by reducing amide compound

The invention relates to a method for preparing an amine compound by reducing an amide compound, which comprises the following steps: in a protective atmosphere, mixing the amide compound or cyclic amide, a zirconium metal catalyst and pinacol borane, carrying out amide reduction reaction at room temperature, and carrying out aftertreatment by using an ether solution of hydrogen chloride after 12-48 hours to obtain an amine hydrochloride compound. The method is simple to operate, low in cost, good in functional group tolerance and wide in substrate range.

Frustrated Lewis Pair Catalyzed Hydrogenation of Amides: Halides as Active Lewis Base in the Metal-Free Hydrogen Activation

A method for the metal-free reduction of carboxylic amides using oxalyl chloride as an activating agent and hydrogen as the final reductant is introduced. The reaction proceeds via the hydrogen splitting by B(2,6-F2-C6H3)3 in combination with chloride as the Lewis base. Density functional theory calculations support the unprecedented role of halides as active Lewis base components in the frustrated Lewis pair mediated hydrogen activation. The reaction displays broad substrate scope for tertiary benzoic acid amides and α-branched carboxamides.

Acid promoted cyclodehydration of amino alcohols with amide acetal

A convenient acid-promoted cyclization protocol for the formation of azaheterocycles from amino alcohols is described. The reaction involves the use of N,N-dimethylacetamide dimethyl acetal (DMADA) as the activating reagent of the hydroxyl group. Using this protocol, pyrrolidines or piperidines with various substituents can be synthesized in good to high yields.

Cross-coupling of mesylated phenol derivatives with potassium ammonio-and amidomethyltrifluoroborates

A large array of aryl and heteroaryl mesylates have been successfully employed as electrophiles in a Csp2-Csp3 Suzuki-Miyaura cross-coupling with potassium ammonio-and amidomethyltrifluoroborates to afford the corresponding products

On the Synthesis of Azetidines from 3-Hydroxypropylamines

New methods are described for preparing azetidines from 3-hydroxypropylamines involving the use of triphenylphosphine and diethyl azodicarboxylate and related reagents.