29393-16-6

Basic information

• Product Name: methyl (2R)-2-methyl-3-phenylpropanoate
• Synonyms: methyl (2R)-2-methyl-3-phenylpropanoate
• CAS NO: 29393-16-6
• Molecular Weight: 178.231
• Mol File: 29393-16-6.mol
• Article Data: 74

Chemical Properties

• CAS DataBase Reference: methyl (2R)-2-methyl-3-phenylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2R)-2-methyl-3-phenylpropanoate(29393-16-6)
• EPA Substance Registry System: methyl (2R)-2-methyl-3-phenylpropanoate(29393-16-6)

Safety Data

• Hazardous Substances Data: 29393-16-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 300-57-2 allylbenzene 
• 201230-82-2 carbon monoxide 
• 1007-32-5 benzyl ethyl ketone 
• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 591-50-4 iodobenzene 
• 103873-64-9 2-Benzyl-2-methyl-malonic acid monomethyl ester 
• 80-62-6 methacrylic acid methyl ester 
• 71-43-2 benzene 
• 18020-59-2 methyl 3-hydroxy-2-methylidene-3-phenylpropionate 
• 124957-36-4 Methyl 3-acetoxy-2-methylene-3-phenylpropanoate 
• 186581-53-3 diazomethane 
• 109-72-8 n-butyllithium 
• 501-52-0 3-Phenylpropionic acid 

Downstream Products

• 1009-67-2 2-methyl-3-phenylpropionic acid 
• 14367-67-0 2-methyl-3-phenylpropionic acid 
• 111654-31-0 2-Methyl-3-phenyl-propionic acid 3-phenoxy-benzyl ester 
• 132398-33-5 4-Methyl-4-benzyl-2-vinylcyclopentanenitrile 
• 132398-27-7 2-Methyl-2-benzyl-6-phenylthio-4-hexenoic acid chloride 
• 132398-29-9 (E)-2-Benzyl-2-methyl-6-phenylsulfanyl-hex-4-enoic acid 4-methyl-2-thioxo-thiazol-3-yl ester 
• 144899-02-5 2-Methyl-2-benzyl-6-phenylthio-4-hexenoic acid 
• 144898-97-5 Methyl 2-methyl-2-benzyl-6-phenylthio-4-hexenoate 
• 144899-19-4 (E)-2-Benzyl-2-methyl-6-phenylsulfanyl-hex-4-enoic acid 2-thioxo-2H-pyridin-1-yl ester 
• 38574-62-8 methyl (S)-(+)-2-benzylpropionate 
• 1276126-20-5 C₃₁H₄₃N₅O₂Si 
• 123820-51-9 ((Z)-1-Methoxy-2-methyl-3-phenyl-propenyloxy)-trimethyl-silane 

Relevant articles and documents

C?Boron Enolates Enable Palladium Catalyzed Carboboration of Internal 1,3-Enynes

A new family of carbon-bound boron enolates, generated by a kinetically controlled halogen exchange between chlorocatecholborane and silylketene acetals, is described. These C?boron enolates are demonstrated to activate 1,3-enyne substrates in the presence of a Pd0/Senphos ligand complex, resulting in the first examples of a carboboration reaction of an alkyne with enolate-equivalent nucleophiles. Highly substituted dienyl boron building blocks are produced in excellent site-, regio-, and diastereoselectivity by the described catalytic cis-carboboration reaction.

Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions

N-Acylpyrrole-type amides are a class of versatile building blocks in asymmetric synthesis. We report that by employing Ni(COD)2/2,2′-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcohols can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50 °C/80 °C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, Nacylindoles, and to other (functionalized) primary and secondary alcohols. In all cases, only 1.5 equiv. of alcohol were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asymmetric methodologies.