2941-48-2

Basic information

• Product Name: Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI)
• Synonyms: Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI);2,5-Dichlor-benzothiazol;2,5-dichloro-1,3-benzothiazole
• CAS NO: 2941-48-2
• Molecular Formula: C₇H₃Cl₂NS
• Molecular Weight: 204.07642
• Product Categories: BENZOTHIAZOLE
• Mol File: 2941-48-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 64-66℃
• Boiling Point: 287℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.567
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.701
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI)(2941-48-2)
• EPA Substance Registry System: Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI)(2941-48-2)

Safety Data

• Hazardous Substances Data: 2941-48-2(Hazardous Substances Data)

Usage

Chemical Properties

Pale yellow solid

InChI:InChI=1/C7H3Cl2NS/c8-4-1-2-6-5(3-4)10-7(9)11-6/h1-3H

Upstream product

• 89-61-2 2,5-dichloronitrobenzene 
• 1889-57-2 (4-chloro-2-nitrophenyl)(methyl)sulfane 
• 16423-54-4 2-amino-4-chlorophenyl methyl sulphide 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 108-42-9 3-chloro-aniline 
• 20174-72-5 (5-chloro-1,3-benzothiazol-2-yl)hydrazine 
• 20358-00-3 2-amino-5-chlorobenzothiazole 
• 52728-54-8 1,1-dimethyl-2-n-propylhydrazine 
• 5331-91-9 5-chloro-2-mercaptobenzothiazole 
• 75-15-0 carbon disulfide 
• 5331-91-9 5-chloro-1,3-benzothiazole-2(3H)-thione 

Downstream Products

• 35412-18-1 5-chloro-N-phenylbenzo[d]thiazol-2-amine 
• 57260-46-5 1-(5-chloro-benzothiazol-2-yl)-4-[3-(4-methoxy-phenyl)-acryloyl]-piperazine 
• 4225-16-5 5-chloro-N,N-dimethylbenzo[d]thiazol-2-amine 
• 108923-25-7 (5-chloro-benzothiazol-2-yl)-nitroso-phenyl-amine 
• 315228-87-6 5-chloro-2-(2-methoxy-4-nitro-phenylsulfanyl)-benzothiazole 
• 1049799-46-3 5-chloro-2-[2-(4'-chlorophenoxy)anilino]-1,3-benzothiazole 
• 1049799-45-2 5-chloro-2-(3,4-dichloroanilino)-1,3-benzothiazole 
• 1340598-18-6 N-{2-[4-(aminosulfonyl)phenyl]ethyl}-1-(5-chloro-1,3-benzothiazol-2-yl)-3-piperidinecarboxamide 
• 2786-51-8 5-chlorobenzo[d]thiazole 

Relevant articles and documents

Ionic Reactivity of 2-Isocyanoaryl Thioethers: Access to 2-Halo and 2-Aminobenzothia/Selenazoles

An ionic cascade insertion/cyclization reaction of thia-/selena-functionalized arylisocyanides has been successfully developed for the efficient and practical synthesis of 2-halobenzothiazole/benzoselenazole derivatives. This synthetic protocol, incorporating a halogen atom when forming the five-membered ring of benzothia/selenazoles, is different from the existing ones, where halogenation of the preformed benzothia/selenazole precursors happens. Additionally, a facile access to 2-aminobenzothiazoles is also achieved by the one-pot cascade reaction of 2-isocyanoaryl thioethers, iodine, and amines.

COMPOUNDS USEFUL AS ANTIBIOTIC TOLERANCE INHIBITORS

The disclosure provides compounds and pharmaceutical compositions of the compounds useful for treating chronic and acute bacterial infections. Certain of the compounds are compounds and salts of general Formula VIII Certain compounds of this disclosure are MvfR inhibitors. MvfR inhibitors reduce the formation of antibiotic tolerant bacterial strains and are useful for treating Gram-negative bacterial infections and reducing the virulence of Pseudomonas aeruginosa. Methods of treating bacterial infections in a patient, including Pseudomonas aeruginosa infections, are also provided by the disclosure.

MICROSOMAL PROSTAGLANDIN E SYNTASE-1 INHIBITORS

This invention relates to piperidine derivatives, to processes for their preparation, to pharmaceutical compositions containing them and to their use in medicine.