294198-22-4

Upstream product

• 292638-85-8 acrylic acid methyl ester 
• 5558-29-2 3-methyl-2-phenyl-butyronitrile 
• 67-56-1 methanol 
• 92250-60-7 (+/-)-4-cyano-5-methyl-4-phenylhexanoic acid 

Downstream Products

• 294198-21-3 4-Cyano-5-methyl-4-phenylhexanol 
• 493006-79-4 (S)-4-cyano-5-methyl-4-phenylhexyl mesylate 
• 352196-07-7 (+/-)-4-cyano-5-methyl-4-phenylhexyl propionate 
• 493006-61-4 (S)-(-)-4-cyano-5-methyl-4-phenylhexyl acetate 
• 352196-06-6 (+/-)-4-cyano-5-methyl-4-phenylhexyl acetate 
• 350795-08-3 (2S)-2-(2-isopropyl)-5-hydroxy-2-phenylpentanenitrile 
• 92250-60-7 (+/-)-4-cyano-5-methyl-4-phenylhexanoic acid 
• 102746-57-6 3-isopropyl-3-phenyl-piperidine-2,6-dione 

Relevant academic research and scientific papers

Enantioselective synthesis of (2S)-5-{4-[2-(4-fluorophenoxy)ethyl]piperazin-1-yl}-2-isopropyl-2-phenyl- pentanenitrile dihydrochloride (E2050) using enzyme-catalyzed kinetic resolution

Immobilized lipase (Pseudomonas sp.)-catalyzed transesterification of (RS)-4-cyano-4-isopropyl-4-phenyl-1-butanol 4 in vinyl acetate gave (S)-4-cyano-4-isopropyl-4-phenyl-1-butyl acetate 3a with high enantiomeric excess values and conversions (95-97% ee,

Nitrile compound

The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitr

NITRILE DERIVATIVES

The present invention provides a novel nitrile compound useful as an intermediate for the production of, for example, N,N-substituted cyclic amine derivatives or phenylacetonitrile derivatives that are useful as a medicine. Specifically it provides a nitrile carboxylic acid compound, nitrile ester compound and nitrile alcohol compound. That is, it provides a nitrile compound represented by the following formula (I): wherein R1 and R2 means substituents; m means 0 or an integer of from 1 to 6; n means 0 or an integer of from 1 to 5; and R3 means carboxyl group, a lower alkoxycarbonyl group or hydroxymethyl group.