352196-07-7Relevant academic research and scientific papers
Enantioselective synthesis of (2S)-5-{4-[2-(4-fluorophenoxy)ethyl]piperazin-1-yl}-2-isopropyl-2-phenyl- pentanenitrile dihydrochloride (E2050) using enzyme-catalyzed kinetic resolution
Norimine, Yoshihiko,Yamamoto, Noboru,Suzuki, Yuichi,Kimura, Teiji,Kawano, Koki,Ito, Koichi,Nagato, Satoshi,Iimura, Yoichi,Yonaga, Masahiro
, p. 1493 - 1502 (2007/10/03)
Immobilized lipase (Pseudomonas sp.)-catalyzed transesterification of (RS)-4-cyano-4-isopropyl-4-phenyl-1-butanol 4 in vinyl acetate gave (S)-4-cyano-4-isopropyl-4-phenyl-1-butyl acetate 3a with high enantiomeric excess values and conversions (95-97% ee,
