294201-15-3Relevant articles and documents
Cyclols Revisited: Facile Synthesis of Medium-Sized Cyclic Peptides
Mendoza-Sanchez, Rodrigo,Corless, Victoria B.,Nguyen, Q. Nhu N.,Bergeron-Brlek, Milan,Frost, John,Adachi, Shinya,Tantillo, Dean J.,Yudin, Andrei K.
, p. 13319 - 13322 (2017)
Medium-sized rings, particularly the corresponding cyclic peptides, are challenging synthetic targets. In the present study, we report an approach to medium-sized cyclic peptides through targeted formation and collapse of cyclol intermediates. This methodology operates on β-amino imides derived from 2,5-diketopiperazines and offers a straightforward transition from frequently examined scaffolds in drug discovery to a rarely visited class of medium-sized rings.