2948-92-7

Basic information

• Product Name: 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE
• Synonyms: 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE;ZERENEX E/5046066
• CAS NO: 2948-92-7
• Molecular Formula: C12H15N3
• Molecular Weight: 201.27
• Mol File: 2948-92-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE(2948-92-7)
• EPA Substance Registry System: 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE(2948-92-7)

Safety Data

• Hazardous Substances Data: 2948-92-7(Hazardous Substances Data)

Usage

General Description

2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole is a chemical compound that consists of a benzimidazole ring with a pyrrolidin-1-ylmethyl side chain. It is used in scientific research as a building block for the synthesis of various organic compounds, particularly in medicinal chemistry for the development of potential pharmaceuticals. 2-(PYRROLIDIN-1-YLMETHYL)-1H-BENZIMIDAZOLE has shown potential activity in the treatment of certain diseases and conditions, and its structure is of interest for the design and development of new drug candidates. The presence of the pyrrolidin-1-ylmethyl group in the molecule may confer specific properties or functional characteristics that could be useful in the development of therapeutic agents. Overall, 2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole is an important chemical for research and development in the field of medicinal chemistry and drug discovery.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 57159-81-6 2-(methylsulfonyl)-1H-benzo[d]imidazole 
• 54600-29-2 1-((trimethylsilyl)methyl)pyrrolidine 
• 134469-07-1 Benzimidazol-2-thiol 
• 7152-24-1 2-methylsulfanylbenzimidazole 
• 4856-97-7 2-(Hydroxymethyl)benzimidazole 
• 123-75-1 pyrrolidine 
• 15784-37-9 2-methyl-1-(phenylsulfonyl)-1H-benzo[d]imidazole 
• 4857-04-9 2-chloromethyl-1H-benzimidazole 

Relevant articles and documents

Synthesis and Pharmacological Activity of C(2)-Substituted Benzimidazoles

Series of new compounds containing 2-pyrrolidinomethyl and 2-piperazinomethyl groups and 2-morpholino and 2-morpholinoethylamine substituents were synthesized. The antiglycation activities of 2-(morpholin-4-yl)-1-(propen-2-en-1-yl)-1H-benzimidazole and 2-(morpholin-4-yl)-1-[2-(morpholin-4-yl)ethyl]-1H-benzimidazole were comparable to that of aminoguanidine. Some compounds exhibited moderate antiserotonin, anti-angiotensin, antioxidant, and dipeptidyl peptidase-4 (DPP-4) inhibitory effects.

METHODS AND COMPOSITIONS FOR TREATING EPILEPSY

Provided, inter alia, are methods and compositions for treating epilepsy. In one aspect, provided herein is a method of selecting a compound for treating epilepsy, said method includes, contacting a test compound with 5-hydroxytryptamine-2B receptor (5-HT2B), and measuring the 5-HT2B agonistic activity of the test compound. In another aspect, provided herein is a method of treating an epilepsy in a subject in need thereof. The method includes administering to said subject an effective amount of a 5-HT2B specific receptor agonist.

Selective inhibition of heme oxygenase-2 activity by analogs of 1-(4-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole): Exploration of the effects of substituents at the N-1 position

Several analogs based on the lead structure of 1-(4-chlorobenzyl)-2- (pyrrolidin-1-ylmethyl)-1H-benzimidazole (clemizole) were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). Many of the compounds were found to be potent and highly s