29555-25-7

Upstream product

• 90-02-8 salicylaldehyde 
• 99-73-0 para-bromophenacyl bromide 
• 86293-49-4 (E)-1-(4-bromophenyl)-3-(2-hydroxyphenyl)prop-2-en-1-one 
• 99-90-1 para-bromoacetophenone 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 6047-83-2 (4-bromophenacyl)dimethylsulfanium bromide 
• 68-12-2 N,N-dimethyl-formamide 
• 27038-01-3 (4-bromo-phenyl)-(3-hydroxy-2,3-dihydro-benzofuran-2-yl)-methanone 
• 4209-02-3 1-(4-bromophenyl)-2-chloroethan-1-one 

Downstream Products

• 3611-64-1 benzofuran-2-yl(4-bromophenyl)methanol 
• 887908-75-0 benzo[b]furan-2-yl-(4'-chlorobiphenyl-4-yl)-methanone 
• 82158-42-7 [1,1′-biphenyl]-4-yl(benzofuran-2-yl)methanone 
• 82158-27-8 [1,1′-biphenyl]-4-yl(benzofuran-2-yl)methanol 
• 887908-76-1 benzo[b]furan-2-yl-(4'-chlorobiphenyl-4-yl)-methanol 

Relevant academic research and scientific papers

Synthesis method of benzofuran compound

The invention belongs to the field of organic chemical synthesis, and particularly relates to a synthesis method of a benzofuran compound. According to the invention, the reaction system adopts economical and efficient iron phthalocyanine as a catalyst, a

Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies

Thirty benzofuran-2-yl(phenyl)methanones 1–30 were synthesized and characterized their structures by spectroscopic techniques. Substituted phenacyl bromide and different derivatives of 2-hydroxy-benzaldehyde treated in the presence of anhydrous K2/s

Syntheses of 2-Aroyl Benzofurans through Cascade Annulation on Arynes

The highly efficient and expedient route for the syntheses of 2-aroyl benzofurans has been developed via the cascade [2+2] followed by a [4+1] annulation on arynes. The overall transformation proceeded through the formation of ortho-quinone methide by the

2,3-Diaroyl benzofurans from arynes: Sequential synthesis of 2-aroyl benzofurans followed by benzoylation

A cascade synthetic strategy for the direct synthesis of 2-aroyl benzofurans from aryne precursors has been developed. This reaction proceeds via C-O and C-C bond cleavage as well as C-O and C-C bond formation in a single reaction vessel. The methodology provides good yields of 2-aroyl benzofurans and tolerates a variety of functional groups. The synthesized 2-aroyl benzofurans were further benzoylated at 3-positions and one of the synthesized 2,3-diaroyl benzofuran structures was confirmed unambiguously by X-ray crystallography.

Copper(I)-Catalyzed Chemoselective Reduction of Benzofuran-2-yl Ketones to Alcohols with B2pin2 via a Domino-Borylation-Protodeboronation Strategy

A novel copper(I)-catalyzed chemoselective reduction of the carbonyls of benzofuran-2-yl ketones over furan rings with B2pin2 has been developed. This reaction proceeded under mild conditions. High valuable secondary alcohol derivatives of benzofurans were obtained in good to excellent yields with a broad substrate scope. The mechanistic studies suggested that a domino-borylation-protodeboronation pathway was involved in this reaction.

Synthesis, characterization, and antimicrobial activity of new benzofuran derivatives

A novel series of (5-substituted-1-benzofuran-2-yl)(2,4-substituted phenyl)methanones (4a–4i) have been prepared by the Knoevenagel condensation of (5-substituted-1-benzofuran-2-yl)(2,4-substituted phenyl)methanone (3a–3i) with Meldrum’s acid. The structu

Mechanochemical solid-state synthesis of 2-aminothiazoles, quinoxalines and benzoylbenzofurans from ketones by one-pot sequential acid- and base-mediated reactions

α-Chloroketones-obtained by the atom-economical chlorination of ketones with trichloroisocyanuric acid (TCCA) in the presence of p-TSA under ball-milling conditions-were set up for a sequential base-mediated condensation reaction with thiourea/thiosemicarbazides, o-phenylenediamine and salicylaldehyde to afford 2-aminothiazoles, 2-hydrazinylthiazoles, quinoxalines and benzoylbenzofurans, respectively, in respectable yields. The viability of one-pot sequential acid- and base-mediated reactions in the solid state under ball-milling conditions is thus demonstrated.

Intramolecular oxidative coupling: I2/TBHP/NaN3-mediated synthesis of benzofuran derivatives

A novel intramolecular oxidative coupling reaction has been established to prepare benzofuran derivatives via direct C(sp2)-H functionalization for the formation of C-O bond. This transformation is mediated by I2/TBHP/NaN3 under metal-free conditions and a catalytic amount of NaN3 plays a crucial role in the reaction. Furthermore, the reaction tolerates a broad substrate scope with average to excellent yields.

DABCO-promoted efficient and convenient synthesis of benzofurans

An efficient and convenient synthesis of benzofurans has been described from phenacyl halides and o-hydroxy benzaldehyde in the presence of DABCO. The procedure is applicable for a variety of phenacyl halides and provide a variety of benzofurans. DABCO ac