296282-46-7

Usage

General Description

2-amino-2-hydroxymethyl-4-(4-octyl-phenyl)-butyric acid, also known as AHMBOB, is a chemical compound with potential pharmaceutical applications. It is a derivative of 4-aminobutyric acid and contains an added octyl-phenyl group, which may impart unique pharmacological properties. Studies have shown that AHMBOB may have potential as an anti-inflammatory and antioxidant agent, making it a target for drug development for conditions such as arthritis and neurodegenerative diseases. Its chemical structure and properties make it a promising candidate for further research and potential therapeutic use.

Upstream product

• 296282-78-5 N-[1-cyano-1-hydroxymethyl-3-(4-octylphenyl)propyl]acetamide 
• 111-64-8 n-octanoic acid chloride 
• 103-45-7 acetic acid phenethyl ester 
• 162358-07-8 2-(4-octylphenyl)-1-iodoethane 
• 162358-05-6 2-(4-Octylphenyl)ethyl alcohol 
• 162358-04-5 acetic acid 2-(4-octylphenyl)ethyl ester 
• 162358-06-7 4-octylphenethyl methanesulfonate 
• 162358-03-4 2-(4-octanoylphenyl)ethyl acetate 
• 296282-66-1 ethyl 2-acetamido-2-cyano-4-(4-octylphenyl)butyrate 

Relevant academic research and scientific papers

Synthesis and immunosuppressive activity of 2-substituted 2- aminopropane-1,3-diols and 2-aminoethanols

A series of 2-substituted 2-aminopropane-1,3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat skin allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, which is an immunosuppressive agent structurally simplified from myriocin (1, ISP-I) via compound 2. The potency of the various compounds was dependent upon the position of the phenyl ring within the alkyl side chain. The most suitable length between the quaternary carbon atom and the phenyl ring was two carbon atoms. 2-Substituted 2-aminoethanols were successively synthesized and evaluated for their T-cell-decreasing effect and immunosuppressive effect using a popliteal lymph node gain assay in rats. The absolute configuration at the quaternary carbon affected the activity, and the (pro-S)-hydroxymethyl group of compound 6 was essential for potent immunosuppressive activity. Favorable substituents for the (pro-R)- hydroxymethyl group of 6 were hydroxyalkyl (hydroxyethyl and hydroxypropyl) or lower alkyl (methyl and ethyl) groups. 2-Amino-2-[2-(4- octylphenyl)ethyl]propane-1,3-diol hydrochloride (6, FTY720) was found to possess considerable activity and is expected to be useful as an immunosuppressive drug for organ transplantation.