29644-99-3

Basic information

• Product Name: 2-(4-methoxyphenyl)butanoic acid
• Synonyms: 2-(4-methoxyphenyl)butanoic acid;2-(p-Methoxyphenyl)butanoic acid
• CAS NO: 29644-99-3
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol File: 29644-99-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 323.2°Cat760mmHg
• Flash Point: 123.8°C
• Appearance: /
• Density: 1.112g/cm³
• Vapor Pressure: 0.000109mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 2-(4-methoxyphenyl)butanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxyphenyl)butanoic acid(29644-99-3)
• EPA Substance Registry System: 2-(4-methoxyphenyl)butanoic acid(29644-99-3)

Safety Data

• Hazardous Substances Data: 29644-99-3(Hazardous Substances Data)

Usage

Classification

Nonsteroidal anti-inflammatory drug (NSAID).

Common uses

Relieving pain, fever, and inflammation.

Medical applications

Arthritis, menstrual cramps, and minor injuries.

Available forms

Tablets, capsules, and topical gel.

Mechanism of action

Inhibits the production of prostaglandins, which cause pain, fever, and inflammation.

Side effects

Stomach ulcers, allergic reactions, and kidney problems (in some individuals).

Precautions

Use cautiously, especially with regular use or high doses.

InChI:InChI=1/C11H14O3/c1-3-10(11(12)13)8-4-6-9(14-2)7-5-8/h4-7,10H,3H2,1-2H3,(H,12,13)

Upstream product

• 108-75-8 2,4,6-trimethyl-pyridine 
• 100060-29-5 2-diazo-1-(4-methoxy-phenyl)-butan-1-one 
• 100-51-6 benzyl alcohol 
• 74-96-4 ethyl bromide 
• 104-47-2 p-methoxybenzylnitrile 
• 60-29-7 diethyl ether 
• 61866-52-2 1-butenyl-4-methoxybenzene 
• 7553-56-2 iodine 
• 104-01-8 4-Methoxyphenylacetic acid 
• 140-67-0 Estragole 
• 124-38-9 carbon dioxide 
• 90875-08-4 (rac)-4-(2-bromopropyl)-1-methoxybenzene 
• 104-46-1 anethole 
• 75-03-6 ethyl iodide 

Downstream Products

• 141426-92-8 4-Nitrophenyl 2-(4'-Methoxyphenyl)butyrate 
• 141427-14-7 2-(4-methoxyphenyl)butanoyl chloride 
• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 
• 1392494-04-0 2-(4-methoxyphenyl)-N-(2-(pyrrolidin-1-yl)phenyl)butanamide 
• 5331-23-7 3,4-bis-(4-methoxy-phenyl)-hexan-3-ol 

Relevant articles and documents

Photoinduced Copper-Catalyzed Asymmetric Decarboxylative Alkynylation with Terminal Alkynes

We describe a photoinduced copper-catalyzed asymmetric radical decarboxylative alkynylation of bench-stable N-hydroxyphthalimide(NHP)-type esters of racemic alkyl carboxylic acids with terminal alkynes, which provides a flexible platform for the construction of chiral C(sp3)?C(sp) bonds. Critical to the success of this process are not only the use of the copper catalyst as a dual photo- and cross-coupling catalyst but also tuning of the NHP-type esters to inhibit the facile homodimerization of the alkyl radical and terminal alkyne, respectively. Owing to the use of stable and easily available NHP-type esters, the reaction features a broader substrate scope compared with reactions using the alkyl halide counterparts, covering (hetero)benzyl-, allyl-, and aminocarbonyl-substituted carboxylic acid derivatives, and (hetero)aryl and alkyl as well as silyl alkynes, thus providing a vital complementary approach to the previously reported method.

Site-Selective, Remote sp3 C?H Carboxylation Enabled by the Merger of Photoredox and Nickel Catalysis

A photoinduced carboxylation of alkyl halides with CO2 at remote sp3 C?H sites enabled by the merger of photoredox and Ni catalysis is described. This protocol features a predictable reactivity and site selectivity that can be modulated by the ligand backbone. Preliminary studies reinforce a rationale based on a dynamic displacement of the catalyst throughout the alkyl side chain.

Highly enantioselective direct alkylation of arylacetic acids with chiral lithium amides as traceless auxiliaries

A direct, highly enantioselective alkylation of arylacetic acids via enediolates using a readily available chiral lithium amide as a stereodirecting reagent has been developed. This approach circumvents the traditional attachment and removal of chiral auxiliaries used currently for this type of transformation. The protocol is operationally simple, and the chiral reagent is readily recoverable.