84289-03-2

Upstream product

• 1127-49-7 5,8-diaminoisoquinoline 
• 2439-04-5 5-hydroxyisoquinoline 
• 54879-54-8 5,8-dimethoxy-3-methyl-2-tosyl-1,2-dihydroisoquinoline 
• 54879-36-6 N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-4-methylbenzenesulfonamide 
• 55087-23-5 5,8-dimethoxyisoquinoline 
• 1432611-60-3 N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide 
• 54879-79-7 acetaldehyde dimethyl acetal 
• 54879-66-2 acetaldehyde dimethyl acetal 
• 93-02-7 2,5-dimethoxybenzaldehyde 
• 1125-60-6 isoquinolin-5-ylamine 
• 607-32-9 5-nitroisoquinoline 
• 156901-61-0 8-amino-5-nitro-isoquinoline 

Downstream Products

• 102072-79-7 6-chloro-7-hydroxy-5,8-isoquinolinedione 
• 228574-27-4 6-chloro-7-((4-methoxyphenyl)amino)isoquinoline-5,8-dione 
• 228574-31-0 6-chloro-7-(2-hydroxyethylphenyl)amino-5,8-isoquinolinedione 
• 296776-09-5 6-chloro-7-(4-isopropylphenyl)amino-5,8-isoquinolinedione 
• 465547-25-5 6-(N'-4-aminoacetanilide)-7-pyrrolidino-5,8-isoquinolinedione 
• 465547-26-6 7-(N'-4-aminoacetanilide)-6-pyrrolidino-5,8-isoquinolinedione 
• 102072-81-1 6-cyano-7-hydroxy-5,8-isoquinolinedione 

Relevant academic research and scientific papers

Benzoquinone derivative, pharmaceutical composition, and applications thereof

The invention discloses a benzoquinone derivative, a pharmaceutical composition, and applications thereof. According to the invention, the benzoquinone derivative (I), and the stereoisomer or the pharmaceutically acceptable salt thereof possess a structure disclosed in the invention. The benzoquinone derivative possesses excellent inhibition effect on STAT3 level both in vivo and in vitro, and further, the benzoquinone derivative is capable of inhibiting balling capacity of cancer cells.

Synthesis and antiproliferative activity of new cytotoxic tri- and tetraazabenzo[3,2-a]fluorene-5,6-dione derivatives

A new series of substituted tri-/tetraazabenzo[3,2-a]fluorene-5,6-diones and their corresponding oxime derivatives have been synthesized and spectroscopically characterized. The antiproliferative activities of all compounds were evaluated on at least thre

Exploitation of a tuned oxidation with N -haloimides in the synthesis of caulibugulones A-D

Marine alkaloids caulibugulones A-D were synthesized in six steps starting from the readily available 2,5-dimethoxybenzaldehyde. Pomeranz-Fritsch reaction of N-(2,5-dimethoxybenzyl)-N-(2,2-dimethoxyethyl)-2-nitrobenzenesulfonamide proceeded smoothly to gi

Synthesis of aminovinyl derivatives of quinoline- and isoquinoline-5,8- diones

Aminovinyl derivatives of quinoline-5,8-dione and isoquinoline-5,8-dione were obtained. The structure of (E)-6-chloro-7-[2-(N,N-diethylamino)vinyl] quinoline-5,8-dione was confirmed by X-ray structural analysis.

Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: Indolizinoquinoline-5,12-dione derivatives

A series of indolizinoquinoline-5,12-dione derivatives (IQDs) are synthesized and evaluated for their cytotoxic activities toward human lung adenocarcinoma (GLC-82), large-cell lung carcinoma (NCI-H460), promyelocytic leukemia (HL-60) and breast carcinoma (MCF-7) cells by MTT method. Most of the IQDs show significant cytotoxic potency. In addition, the evaluation of structure-activity relationships indicated that the incorporation of electron-withdrawing substituents at the C or D ring will enhance the activities of the target compounds distinctly. The topoisomerase I inhibitory activity is also measured.

7-(Substituted-phenyl)amino-5,8-isoquinolinediones: Synthesis and cytotoxic activities on cancer cell lines

6-Chloro-7-(substituted-phenyl)amino-5,8-isoquinolinediones (3a-3u) and 7-(substituted-phenyl)amino-5,8-isoquinolinediones (4a-4d) were synthesized by nucleophilic substitution of 6,7-dichloro-5,8-isoquinolinedione (8) and 5,8-isoquinolinedione (9) with appropriate arylamines. The quinones 3a-3u and 4a-4d were evaluated for in vitro cytotoxic activities against five solid tumor cell lines such as A549, SK-OV-3, SK-MEL-2, XF498 and HCT-15. Among them, 3c, 3d, 3f and 3h exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8- isoquinolinediones

6-Chloro-7-arylamino-5,8-isoquinolinediones were newly synthesized and evaluated for in vitro cytotoxic activities against five human solid tumor cell lines. Among them, 5b, 5c and 5d exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.

OXIDES OF HETEROCYCLIC QUINONES. N-OXIDES AND EPOXIDES OF QUINOLINE- AND ISOQUINOLINE-5,8-DIONE

The syntheses of 6,7-epoxides and N-oxides of quinoline- and isoquinoline-5,8-diones and of their 6,7-dichloro derivatives are described.The key step of synthesis is oxidation of quinoline or isoquinoline N-oxides bearing the hydroxy or amino groups in the position 5 and 8.