29690-21-9

Upstream product

• 700-37-8 4-chloro-2-fluoro-nitrobenzene 
• 23474-98-8 2-amino-5-chlorobenzenethiol 
• 74-88-4 methyl iodide 
• 95-24-9 6-chloro-2-aminobenzothiazole 
• 106-47-8 4-chloro-aniline 
• 624-92-0 Dimethyldisulphide 
• 70019-41-9 4-chloro-2-(methylthio)-1-nitrobenzene 

Downstream Products

• 92014-00-1 2-phenyl-6-chlorobenzothiophene 
• 102153-42-4 1-amino-2-methanesulphonyl-4-chlorobenzene 
• 7466-32-2 6-chloro-2-phenylbenzo[d]thiazole 
• 57946-32-4 N-(4-Chloro-2-methylsulfanyl-phenyl)-C,C,C-trifluoro-methanesulfonamide 

Relevant academic research and scientific papers

Synthesis and insecticidal evaluation of novel sulfide-containing amide derivatives as potential ryanodine receptor modulators

With the aim of discovering new bioactive pesticides for crop protection, a series of novel sulfide-containing amide derivatives A were efficiently synthesized via a strategy of modifying the “amide” structure of anthranilic diamide insecticides. The single-crystal structures of A2-3 and A4-5 were firstly reported. The bioassay results showed that most of the synthesized compounds display moderate to high insecticidal activities. Particularly, some sulfone-containing compounds, e.g., A2-3, A3-3 and A6-3, not only possessed favorable lethality rate (50%–100%) against P. xylostella at a concentration of 0.1 mg/L, but also held good activities towards a variety of agricultural pests such as M. separata, C. pipiens pallen, H. armigera and O. nubilalis; the larvicidal activities of A4-1 and A6-1 towards P. xylostella were close to that of chlorantraniliprole at 0.01 mg/L. The calcium imaging experiments revealed that the representative compounds A2-3 and A6-3 are potential ryanodine receptor (RyR) modulators. The structure–activity relationships were discussed in detail. These results provide useful information for further design and development of novel insecticides.

Ionic Reactivity of 2-Isocyanoaryl Thioethers: Access to 2-Halo and 2-Aminobenzothia/Selenazoles

An ionic cascade insertion/cyclization reaction of thia-/selena-functionalized arylisocyanides has been successfully developed for the efficient and practical synthesis of 2-halobenzothiazole/benzoselenazole derivatives. This synthetic protocol, incorporating a halogen atom when forming the five-membered ring of benzothia/selenazoles, is different from the existing ones, where halogenation of the preformed benzothia/selenazole precursors happens. Additionally, a facile access to 2-aminobenzothiazoles is also achieved by the one-pot cascade reaction of 2-isocyanoaryl thioethers, iodine, and amines.

Facile syntheses of 3-trifluoromethylthio substituted thioflavones and benzothiophenes via the radical cyclization

3-CF3S substituted thioflavones and benzothiophenes were achieved via the reactions of AgSCF3 with methylthiolated alkynones and alkynylthioanisoles, respectively, promoted by persulfate. This protocol possesses good functional group tolerance and high yields. Mechanistic studies suggested that a classic two-step radical process was involved, which includes addition of CF3S radical to triple bond and cyclization with SMe moiety.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Visible light photocatalytic synthesis of benzothiophenes

The photocatalytic reaction of o-methylthio-arenediazonium salts with alkynes yields substituted benzothiophenes regioselectively through a radical annulation process. Green light irradiation of eosin Y initiates the photoredox catalysis. The scope of the reaction was investigated by using various substituted diazonium salts and different alkynes.

Process for preparing (hydrocarbylthio)aromatic amines

(Hydrocarbylthio)aromatic amines are prepared by reacting an aromatic amine, such as an aminobenzene, with a hydrocarbyl disulfide, such as an alkyl disulfide. The reaction is preferably conducted in the presence of a Lewis acid catalyst, such as aluminum chloride.

Metabolites of 2,4-Dichloro-1-nitrobenzene by Mucor javanicus

Metabolism of 2,4-dichloro-1-nitrobenzene (1) by Mucor javanicus AHU 6010 was investigated.In addition to the corresponding benzenamine derivative (2), two novel metabolites detected gas-chromatographically were extracted from the culture medium and isolated.The structures were unequivocally elucidated to be 4-chloro-2-methylthio-1-nitrobenzene (3) and 4-chloro-2-methylthiobenzenamine (4), respectively, by direct comparisons with authentic compounds.It was suggested that two biological reactions, namely, reduction of the nitro group and/or substitution of the ortho-chlorine atom by a methylthio group, were responsible for the formation of these metabolites.