7466-32-2

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General Description

6-chloro-2-phenyl-1,3-benzothiazole is a chemical compound with the molecular formula C13H8ClNS. It is a member of the benzothiazole family of compounds, which are known for their wide range of applications such as in pharmaceuticals, agrochemicals, and materials science. The presence of a chloro group and a phenyl group in the compound gives it unique chemical properties and potential biological activities. This chemical may be used in the development of new drugs or agrochemicals due to its structural characteristics and potential biological activities. Additionally, it may also have applications in materials science due to its potential for modifying the physical and chemical properties of certain materials.

Upstream product

• 5310-28-1 N-(4-chlorophenyl)thiobenzamide 
• 23474-98-8 2-amino-5-chlorobenzenethiol 
• 614-16-4 Benzoylacetonitrile 
• 106-47-8 4-chloro-aniline 
• 100-52-7 benzaldehyde 
• 2866-82-2 N-(4-chlorophenyl)benzamide 
• 98-86-2 acetophenone 
• 2942-10-1 6-chloro-1,3-benzothiazole 
• 100-46-9 benzylamine 
• 98-91-9 thiobenzoic acid 
• 1239903-50-4 N-(4-chloro-2-iodophenyl)triphenyliminophosphrane 
• 1004-00-8 4-chloro-2-aminobenzenethiol 
• 95-24-9 6-chloro-2-aminobenzothiazole 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1379479-34-1 2-([1,1':3',1''-terphenyl]-2'-yl)-6-chlorobenzo[d]thiazole 
• 1379479-35-2 6-chloro-2-(4,4''-dichloro-[1,1':3',1''-terphenyl]-2'-yl)benzo[d]thiazole 
• 1379479-33-0 6-chloro-2-(4,4''-dimethyl-[1,1':3',1''-terphenyl]-2'-yl)benzo[d]thiazole 
• 1242288-73-8 6-chloro-2-(2-fluorophenyl)benzo[d]thiazole 
• 1242286-86-7 6-chloro-2-(2,6-difluorophenyl)benzo[d]thiazole 
• 1242288-47-6 2-(3-nitrophenyl)-6-chlorobenzothiazole 

Relevant academic research and scientific papers

A highly regioselective synthesis of 2-aryl-6-chlorobenzothiazoles employing microwave-promoted Suzuki-Miyaura coupling reaction

Suzuki-Miyaura coupling reactions of 2,6-dichlorobenzothiazole with arylboronic acids, promoted by microwave heating, efficiently produce 2-aryl-6-chlorobenzothiazoles in a highly regioselective manner. This process serves as the foundation for a simple m

Recyclable copper-catalyzed cyclization of o-haloanilides and metal sulfides: An efficient and practical access to substituted benzothiazoles

An efficient heterogeneous copper-catalyzed cyclization of o-haloanilides and metal sulfides has been achieved via the C–S coupling in DMF at 80 or 140 °C in the existence of an MCM-41-bound NHC-Cu(I) catalyst and then intramolecular condensation, delivering a wide range of substituted benzothiazoles in mostly good to high yields. This new MCM-41-NHC-CuI complex can facilely be obtained by a two-step procedure starting from easily accessible and inexpensive reagents and reused more than seven times without any significant loss of its catalytic efficiency. The present protocol has been successfully applied to the gram-scale synthesis of two antitumor agents 5F203 and PMX 610.

Graphene oxide-catalyzed synthesis of benzothiazoles with amines and elemental sulfur via oxidative coupling strategy of amines to imines

The graphene oxide-catalyzed coupling and cyclization reactions of primary amines with elemental sulfur was developed to afford various optically property benzothiazoles. This coupling and cyclization strategies proceeded under the oxidant system graphene oxide/O2 and constructed carbon-heteroatom (N, S) bonds with amines and elemental sulfur. Due to benzothiazoles as common chromophores, these products exhibited intriguing fluorescence properties, including outstanding Stokes shifts (up to 161 nm) and quantum yields (up to 74%). Utilizing the products’ unique fluorescence response in different solvents, β-naphthothiazole 4a showed excellent aggregation-induced emission properties in 1,2-dichloroethane, which was 60 times higher than in tetrahydrofuran.

Visible-Light Carbon Nitride-Catalyzed Aerobic Cyclization of Thiobenzanilides under Ambient Air Conditions

A metal-free heterogeneous photocatalysis has been developed for the synthesis of benzothiazoles via intramolecular C-H functionalization/C-S bond formation of thiobenzanilides by inexpensive graphitic carbon nitride (g-C3N4) under visible-light irradiation. This reaction provides access to a broad range of 2-substituted benzothiazoles in high yields under an air atmosphere at room temperature without addition of a strong base or organic oxidizing reagents. In addition, the catalyst was found to be stable and reusable after five reaction cycles.

Photocatalyst- And Transition-Metal-Free Visible-Light-Promoted Intramolecular C(sp2)-S Formation

A photocatalyst- and transition-metal-free visible-light-induced cyclization of ortho-halothiobenzanilides has been developed. Upon irradiation with visible light, substrates undergo dehalogenative cyclization to 2-aryl benzothiazoles with high efficiency and selectivity. This photocyclization exhibits a high tolerance to various functional groups, is applicable for the synthesis of 2-alkyl benzothiazoles, and is easy to set up for gram-scale reaction.

Method for preparing benzothiazole compound from visible light promoted N-(2-bromophenyl) thioamide

The invention discloses a method for preparing a benzothiazole compound from N-(2-bromophenyl) thioamide under the promotion of visible light. Specifically, under the protection of inert gas, according to the molar ratio of N-(2-bromophenyl) thioamide to inorganic base being 1: 0.5, reactants are added into a reaction container provided with a stirring device, then dimethyl sulfoxide is added, and stirring reaction is carried out for 2-24 hours at room temperature under the irradiation of visible light to obtain the benzothiazole compound. Under the condition of not adding any photosensitizer or transition metal catalyst, sodium phosphate is used as alkali, and under the irradiation of a 45W household compact fluorescent lamp, a series of intramolecular cross-coupling reactions of N-(2-bromophenyl) thioamide are realized. In addition, the benzothiazole compound can be obtained with high yield. The whole process is green, efficient and easy to operate, and the method is a good method for synthesizing the benzothiazole compound.

Preparation method of 2-substituted benzothiazole

The invention discloses a preparation method of 2-substituted benzothiazole, and belongs to the field of organic chemical synthesis. The preparation method of the 2-substituted benzothiazole specifically comprises the following steps: by taking an N-aryl thioamide compound as a raw material and taking graphite-phase carbon nitride (g-C3N4) prepared by urea thermal polymerization condensation as aphotocatalyst, carrying out a cyclization reaction under a mild condition to prepare the 2-substituted benzothiazole. The method has the advantages of simple operation, cheap and easily available catalyst, mild reaction conditions, wide substrate application range, no strong oxidant and no metal residue, and provides an economical, practical, green and environment-friendly new method for synthesisof 2-substituted benzothiazole widely applied to the fields of medicines, dyes, pesticides and the like.

Riboflavin as Photoredox Catalyst in the Cyclization of Thiobenzanilides: Synthesis of 2-Substituted Benzothiazoles

Benzothiazoles are synthesized from thiobenzanilides using riboflavin as a photosensitizer and potassium peroxydisulfate as a sacrificial oxidizing agent under visible light irradiation. The methodology accepts a broad range of functional groups and affords the 2-substituted benzothiazoles by transition-metal-free organic photoredox catalysis under very mild conditions.

Copper-Catalyzed Aerobic Oxidation of Amines to Benzothiazoles via Cross Coupling of Amines and Arene Thiolation Sequence

A one-pot three-component synthesis of benzothiazoles has been developed using the copper-catalyzed aerobic cross coupling of amines followed by arene thiolation using elemental sulfur. The dual roles of elemental sulfur and CuCl(OH)-TMEDA in the aerobic amine oxidation and the aniline thiolation enable the facile access to benzothiazole derivatives from readily available starting materials. The operational simplicity of the current promiscuous catalyst system suggests the high synthetic potential in the preparation of heterocyclic compounds. (Figure presented.).

Exogenous Photosensitizer-, Metal-, and Base-Free Visible-Light-Promoted C-H Thiolation via Reverse Hydrogen Atom Transfer

Visible-light-driven, intramolecular C(sp2)-H thiolation has been achieved without addition of a photosensitizer, metal catalyst, or base. This reaction induces the cyclization of thiobenzanilides to benzothiazoles. The substrate absorbs visible light, and its excited state undergoes a reverse hydrogen-atom transfer (RHAT) with 2,2,6,6-tetramethylpiperidine N-oxyl to form a sulfur radical. The addition of the sulfur radical to the benzene ring gives an aryl radical, which then rearomatizes to benzothiazole via RHAT.