297173-60-5

Upstream product

• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 
• 598-21-0 2-Bromoacetyl bromide 

Downstream Products

• 297173-62-7 1-[2'-N,N-di(phenylmethyl)amino]ethanoyl-3,4(S)-dimethyl-5(R)-phenylimidazolidin-2-one 
• 364783-86-8 1-[3'(S)-hydroxy-2'(R)-di(phenylmethyl)amino-3-(4-methoxy)phenyl]propionyl-3,4(R)-dimethyl-5(S)-phenylimidazolidin-2-one 
• 364783-70-0 1-[2'(R)-di(phenylmethyl)amino-3'-oxo-3'-phenyl]propionyl-3,4(S)-dimethyl-5(R)-phenylimidazolidin-2-one 
• 297173-63-8 1-[3'(S)-hydroxy-2'(R)-di(phenylmethyl)amino-3-phenyl]propionyl-3,4(R)-dimethyl-5(S)-phenylimidazolidin-2-one 
• 297173-68-3 (4S,5R)-1-((2R,3S)-2-Dibenzylamino-3-hydroxy-hexanoyl)-3,4-dimethyl-5-phenyl-imidazolidin-2-one 
• 297173-69-4 1-[3'(S)-hydroxy-2'(R)-di(phenylmethyl)amino-3'-furyl]propionyl-3,4(R)-dimethyl-5(S)-phenylimidazolidin-2-one 

Relevant academic research and scientific papers

A practical method for the acylation of 2-imidazolidinone and 2-oxazolidinone chiral auxiliaries with 2-bromoacyl halides

Optimised conditions for the acylation of (S)-4-(1-methyl-ethyl)-oxazolidin-2-one 4, (R)-4-phenyloxazolidin-2-one 5 and 4-(R), (5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 3 with 2-bromoacyl halides were developed. For imidazolidin-2-one 3 the optimum con

syn-Selective boron mediated aldol condensations for the asymmetric synthesis of β-hydroxy-α-amino acids

Imidazolidinone-bound glycine enolate derivatives have been shown to undergo aldol condensation with aromatic and aliphatic aldehydes in good yields and with excellent stereocontrol (62-84%, 93-95% d.e.). Removal of the pendant imidazolidinone auxiliary and hydrogenolysis affords the β-hydroxy- α-amino acid derivatives. (C) 2000 Elsevier Science Ltd.