297173-63-8

Upstream product

• 100-52-7 benzaldehyde 
• 297173-62-7 1-[2'-N,N-di(phenylmethyl)amino]ethanoyl-3,4(S)-dimethyl-5(R)-phenylimidazolidin-2-one 
• 297173-60-5 (4S,5R)-1-(2'-bromoethanoyl)-3,4-dimethyl-5-phenylimidazolidin-2-one 
• 92841-65-1 (4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one 

Downstream Products

• 87936-34-3 methyl (2R,3S)-2-amino-3-hydroxy-3-phenylpropanoate 
• 364783-78-8 2(R)-di(phenylmethyl)amino-3(S)-hydroxy-3-phenylpropionic acid, methyl ester 

Relevant academic research and scientific papers

syn-Selective boron mediated aldol condensations for the asymmetric synthesis of β-hydroxy-α-amino acids

Imidazolidinone-bound glycine enolate derivatives have been shown to undergo aldol condensation with aromatic and aliphatic aldehydes in good yields and with excellent stereocontrol (62-84%, 93-95% d.e.). Removal of the pendant imidazolidinone auxiliary and hydrogenolysis affords the β-hydroxy- α-amino acid derivatives. (C) 2000 Elsevier Science Ltd.