29740-75-8

Upstream product

• 100-00-5 4-chlorobenzonitrile 
• 609-08-5 Diethyl methylmalonate 
• 131675-32-6 dimethyl 2-methyl-2-(4-nitrophenyl)malonate 
• 4033-88-9 2-(4-nitrophenyl)malonic acid dimethyl ester 
• 350-46-9 4-Fluoronitrobenzene 
• 50-00-0 formaldehyd 
• 100-12-9 4-ethylnitrobenzene 

Downstream Products

• 1402581-64-9 1-[[2-(3-chlorophenyl)-5-(trifluoromethyl)-2H-pyrazol-3-yl]methyl]-3-[4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea 
• 1402581-66-1 1-[[5-tert-butyl-2-(3-chlorophenyl)-2H-pyrazol-3-yl]methyl]-3-[4-[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]phenyl]urea 
• 1236061-26-9 2-(4-aminophenyl)-2-methylpropane-1,3-diol 
• 1402585-95-8 phenyl 4-(1,3-dihydroxy-2-methylpropan-2-yl)phenylcarbamate 

Relevant academic research and scientific papers

SUBSTITUTED PYRAZOLYL-BASED CARBOXAMIDE AND UREA DERIVATIVES BEARING A PHENYL MOIETY SUBSTITUTED WITH AN O-CONTAINING GROUP AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted pyrazolyl-based carboxamide and urea derivatives of formula (Q) as vanilloid receptor ligands, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.

Electrogenerated Base (EG Base) Induced Hydroxymethylation of the Side Chain of Nitroalkylbenzenes with Paraformaldehyde

Hydroxymethylation of nitroalkylbenzenes with paraformaldehyde was accomplished by electrolysis in a (CH2O)n-DMF-Et4NOTs-(Pt electrode) system.The reaction was found to be catalytic (0.25 faraday/mol) and dependent on the electroreduction of formaldehyde and/or nitroalkylbenzene.A variety of nitroalkylbenzenes were transformed to their corresponding mono- and/or bishydroxymethylated derivatives in good yield.The product yield and selectivity were shown to depend on the order of reagent addition, solvent, supporting electrolyte, and structure of the starting nitroalkylbenzenes.A plausible mechanism of the generation of base catalysts (EG base) in electroreductive media is discussed.