2977-54-0

Upstream product

• 1984-59-4 2,3-dichloroanisole 
• 105-36-2 ethyl bromoacetate 
• 75-36-5 acetyl chloride 
• 2977-53-9 1-(2,3-dichloro-4-hydroxyphenyl)ethan-1-one 

Downstream Products

• 142891-58-5 <2,3-Dichlor-4-<3-(3-nitrophenyl)-1-oxo-2-propenyl>phenoxy>essigsaeure 
• 142891-59-6 <2,3-Dichlor-4-<3-(4-nitrophenyl)-1-oxo-2-propenyl>phenoxy>essigsaeure 
• 29360-58-5 [2,3-Dichloro-4-(2,2-dicyano-1-methyl-vinyl)-phenoxy]-acetic acid 
• 59031-33-3 (2,3-Dichloro-4-vinyl-phenoxy)-acetic acid 
• 142891-65-4 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridin-2-yl>phenoxy>essigsaeuremethylester 
• 142891-64-3 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridin-2-yl>phenoxy>essigsaeuremethylester 
• 142891-63-2 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(2-nitrophenyl)-1,4-dihydropyridin-2-yl>phenoxy>essigsaeuremethylester 
• 142891-71-2 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(4-nitrophenyl)-pyridin-2-yl>phenoxy>essigsaeuremethylester 
• 142891-69-8 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(2-nitrophenyl)-pyridin-2-yl>phenoxy>essigsaeuremethylester 
• 142891-70-1 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-pyridin-2-yl>phenoxy>essigsaeuremethylester 
• 142891-67-6 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridin-2-yl>phenoxy>essigsaeure 
• 142891-68-7 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(4-nitrophenyl)-1,4-dihydropyridin-2-yl>phenoxy>essigsaeure 
• 142891-66-5 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(2-nitrophenyl)-1,4-dihydropyridin-2-yl>phenoxy>essigsaeure 
• 142891-72-3 <2,3-Dichlor-4-<3-methoxycarbonyl-2-methyl-4-(2-nitrophenyl)-pyridin-2-yl>phenoxy>essigsaeure 

Relevant academic research and scientific papers

A two-aromatic substituted propylene ketone compound and its preparation method and application (by machine translation)

The present invention discloses a two-aromatic substituted propylene ketone compound and its preparation method and application, its structural formula such as formula (I) as shown: Wherein A is B is hydrogen, methyl or ethyl; C is a substituted benzene ring, pyridine and furan heterocyclic, 2 - pyridyl, 3 - pyridyl, 4 - pyridyl, 5 - 1 H - indolyl, 4 - (N, N - dimethylamino) phenyl, 4 - (N - pyrrolyl) phenyl, 4 - [1 - (N - methyl piperazinyl)] phenyl or 4 - (1 - morpholinyl) phenyl. The compounds of the invention has a novel structure, to inhibit the cells MCL active effect, high safety, the preparation cost is low and the like, can be used as a MCL very promising drug. (by machine translation)

Identification of a novel class of covalent modifiers of hemoglobin as potential antisickling agents

Aromatic aldehydes and ethacrynic acid (ECA) exhibit antipolymerization properties that are beneficial for sickle cell disease therapy. Based on the ECA pharmacophore and its atomic interaction with hemoglobin, we designed and synthesized several compounds-designated as KAUS (imidazolylacryloyl derivatives)-that we hypothesized would bind covalently to βCys93 of hemoglobin and inhibit sickling. The compounds surprisingly showed weak allosteric and antisickling properties. X-ray studies of hemoglobin in complex with representative KAUS compounds revealed an unanticipated mode of Michael addition between the β-unsaturated carbon and the N-terminal αVal1 nitrogen at the α-cleft of hemoglobin, with no observable interaction with βCys93. Interestingly, the compounds exhibited almost no reactivity with the free amino acids, l-Val, l-His and l-Lys, but showed some reactivity with both glutathione and l-Cys. Our findings provide a molecular level explanation for the compounds biological activities and an important framework for targeted modifications that would yield novel potent antisickling agents.