29847-13-0Relevant academic research and scientific papers
Synthesis and in vitro anticancer activity evaluation of novel bioreversible phosphate inositol derivatives
Chen, Wenbin,Deng, Zhaohui,Chen, Kuangyu,Dou, Daolei,Song, Fanbo,Li, Luyuan,Xi, Zhen
, p. 172 - 181 (2015/03/05)
The chemistry and biology of phosphorylated inositols have become intense areas of research during the last two decades due to their involvement in various cellular signaling processes. However, the metabolic instability by phosphatases or kinases and poo
INOSITOL-BASED MOLECULAR TRANSPORTERS AND PROCESSES FOR THE PREPARATION THEREOF
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Page/Page column 22-23, (2008/06/13)
Inositol derivatives in accordance with the present invention are effective in significantly enhancing the transportation of various therapeutic molecules across a biological membrane, which may include the plasma membrane, nuclear membrane or blood-brain barrier.
Synthesis of all possible regioisomers of scyllo-inositol phosphate
Chung, Sung-Kee,Kwon, Yong-Uk,Chang, Young-Tae,Sohn, Kwang-Hoon,Shin, Jung-Han,Park, Kyu-Hwan,Hong, Bong-Jin,Chung, In-Hee
, p. 2577 - 2589 (2007/10/03)
scyllo-Inositol is the all equatorial stereoisomer of myo-inositol. All possible 12 regioisomers of scyllo-inositol phosphate were synthesized for the first time via a scyllo-inositol benzoate intermediate, which was derived from a myo-inositol derivative. The stereoinversion of myo-inositol into scyllo-inositol was accomplished by Mitsunobu reaction of the vicinal cis- diol. The requisite intermediates, scyllo-inositol benzoates were obtained by benzoyl migration or random benzoylation, and phosphorylated to give scyllo- IP(n). (C) 1999 Elsevier Science Ltd.
Synthesis of (±) 1,2-dideoxy-1,2-diamino-myo-inositol
Guedat, Philippe,Spiess, Bernard,Schlewer, Gilbert
, p. 7375 - 7378 (2007/10/02)
Starting from myo-inositol, an isostere, diaminated in positions 1 and 2, was prepared. The key step of the synthesis was the simultaneous inversion of the dimesylate 6 with sodium azide leading to the global retention of the configuration.
Synthesis and Tritium Radiolabelling of Fluorinated Analogues of myo-Inositol
Offer, John L.,Voorheis, H. Paul,Metcalfe, James C.,Smith, Gerry A.
, p. 953 - 960 (2007/10/02)
Syntheses have been developed for a set of six myo-inositol analogues from myo-inositol in which single hydroxy groups have been replaced by fluorine (monodeoxy-fluoro-myo-inositols).Except for 2-deoxy-2-fluoro-myo-inositol 32 and 1D-4-deoxy-4-fluoro-myo-
Total Synthesis of Fluorinated Analogues of Inositol and Inositol 1,4,5-Trisphosphate
Sawyer, Deborah A.,Potter, Barry V. L.
, p. 923 - 932 (2007/10/02)
Syntheses of fluorinated analogues of inositol and inositol 1,4,5-trisphosphate are described. 1-Deoxy-1-fluoro-scyllo-inositol, 2-deoxy-2,2-difluoro-myo-inositol, DL-2-deoxy-2-fluoro-scyllo-inositol 1,4,5-trisphosphate and DL-2-deoxy-2,2-difluoro-myo-ino
The Allyl Group for Protection in Carbohydrate Chemistry. Part 18. Allyl and Benzyl Ethers of myo-Inositol. Intermediates for the Synthesis of myo-Inositol Triphosphates
Gigg, Jill,Gigg, Roy,Payne, Sheila,Conant, Robert
, p. 423 - 430 (2007/10/02)
Racemic 1,2:4,5-di-O-isopropylidene-myo-inositol was converted into racemic 1,2,4-tri-O-benzyl-myo-inositol, 1,2,4-tri-O-p-methoxybenzyl-myo-inositol and 2,4,5-tri-O-benzyl-myo-inositol using allyl groups for 'temporary' protection.The benzyl ethers are required as intermediates for the synthesis of the 'second messenger', inositol 1,4,5-triphosphate and its metabolite, inositol 1,3,4-triphosphate. 1,2,3,4-Tetra-O-benzyl-myo-inositol, and its two monoallyl and monoprop-1-enyl ethers, were also prepared as model compounds for phosphorylation studies of the vicinal 5,6-diol system which occurs in 1,2,4-tri-O-benzyl-myo-inositol.
