299173-58-3Relevant academic research and scientific papers
CCR2B receptor antagonists: Conversion of a weak HTS hit to a potent lead compound
Forbes, Ian T,Cooper, David G.,Dodds, Emma K.,Hickey, Deirdre M.B.,Ife, Robert J.,Meeson, Malcolm,Stockley, Martin,Berkhout, Theo A.,Gohil, Jayneeta,Groot, Pieter H.E.,Moores, Kitty
, p. 1803 - 1806 (2000)
A weak HTS hit at the CCR2B receptor has been converted into a potent antagonist by array SAR studies. Selectivity over the closely related CCR5 receptor is also achieved. (C) 2000 Elsevier Science Ltd. All rights reserved.
CCR2: Characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach
Berkhout, Theo A.,Blaney, Frank E.,Bridges, Angela M.,Cooper, David G.,Forbes, Ian T.,Gribble, Andrew D.,Groot, Pieter H. E.,Hardy, Adam,Ife, Robert J.,Kaur, Rejbinder,Moores, Kitty E.,Shillito, Helen,Willetts, Jennifer,Witherington, Jason
, p. 4070 - 4086 (2007/10/03)
We describe here a classical molecular modeling exercise that was carried out to provide a basis for the design of novel antagonist ligands of the CCR2 receptor. Using a theoretical model of the CCR2 receptor, docking studies were carried out to define pl
