603152-34-7Relevant academic research and scientific papers
Synthesis and structure-activity relationships of 3-phenyl-2-propenamides as inhibitors of glycogen phosphorylase a
Li, Yue H.,Coppo, Frank T.,Evans, Karen A.,Graybill, Todd L.,Patel, Mehul,Gale, Jennifer,Li, Hu,Tavares, Francis,Thomson, Stephen A.
, p. 5892 - 5896 (2007/10/03)
A series of 3-phenyl-2-propenamides discovered from a high-throughput screening campaign as novel, potent, glucose-sensitive inhibitors of human liver glycogen phosphorylase a is described. A solid-phase synthesis on DMHB resin was also developed which pr
CCR2: Characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach
Berkhout, Theo A.,Blaney, Frank E.,Bridges, Angela M.,Cooper, David G.,Forbes, Ian T.,Gribble, Andrew D.,Groot, Pieter H. E.,Hardy, Adam,Ife, Robert J.,Kaur, Rejbinder,Moores, Kitty E.,Shillito, Helen,Willetts, Jennifer,Witherington, Jason
, p. 4070 - 4086 (2007/10/03)
We describe here a classical molecular modeling exercise that was carried out to provide a basis for the design of novel antagonist ligands of the CCR2 receptor. Using a theoretical model of the CCR2 receptor, docking studies were carried out to define pl
