30014-87-0Relevant academic research and scientific papers
Coumestan inhibits radical-induced oxidation of DNA: Is hydroxyl a necessary functional group?
Xi, Gao-Lei,Liu, Zai-Qun
, p. 5636 - 5642 (2014/07/07)
Coumestan is a natural tetracycle with a C - C bond shared by a coumarin moiety and a benzofuran moiety. In addition to the function of the hydroxyl group on the antioxidant activity of coumestan, it is worth exploring the influence of the oxygen-abundant
Coumestan inhibits radical-induced oxidation of dna: Is hydroxyl a necessary functional groupΔ
Xi, Gao-Lei,Liu, Zai-Qun
, p. 5636 - 5642 (2015/04/22)
Coumestan is a natural tetracycle with a C=C bond shared by a coumarin moiety and a benzofuran moiety. In addition to the function of the hydroxyl group on the antioxidant activity of coumestan, it is worth exploring the influence of the oxygen-abundant s
Antitrypanosomal and antioxidant properties of 4-hydroxycoumarins derivatives
Perez-Cruz, Fernanda,Serra, Silvia,Delogu, Giovanna,Lapier, Michel,Maya, Juan Diego,Olea-Azar, Claudio,Santana, Lourdes,Uriarte, Eugenio
experimental part, p. 5569 - 5573 (2012/09/25)
In the present communication we prepared a series of six 4-hydroxycoumarin derivatives, isosters of quercetin, recognized as an antioxidant natural compound, with the aim of evaluating the antitrypanosomal activity against Trypanosoma cruzi, the parasite
A different route to 3-aryl-4-hydroxycoumarins
Rodríguez, Sergio A.,Baumgartner, Maria T.
experimental part, p. 5322 - 5324 (2010/11/05)
We herein report the simple and direct arylation of 4-hydroxycoumarins by photoinduced reaction with aryl halides (iodobenzene, iodonaphthalene, 4-iodoanisole, 2-iodoanisole). Good yields of 3,4-disubstituted coumarins were obtained in these reactions (>60%). Extension of the procedure to the reaction with o-dihalobenzenes leads to the synthesis of ring closure products which bear a tetracyclic aromatic-condensed ring system, although in lower overall yields (≈45%).
Phenyliodonium zwitterion as an efficient electrophile in the palladium-catalyzed suzuki-type reaction: A novel method for the synthesis of 3-aryl-4-hydroxycoumarins
Zhu, Qiang,Wu, Jie,Fathi, Reza,Yang, Zhen
, p. 3333 - 3336 (2007/10/03)
equation presented A palladium-catalyzed coupling reaction of phenyliodonium zwitterions with aryl boronic acids has been developed. The unique characteristics of the mild reaction conditions and convenient synthetic accessibility of phenyliodonium zwitterions make this method a valuable tool for generating diversified 3-aryl-4-hydroxycoumarins.
