30120-73-1

Upstream product

• 75-36-5 acetyl chloride 
• 615-71-4 benzene-1,2,4-triamine 
• 552-32-9 o-nitroacetanilide 
• 30152-85-3 N,N'-diacetyl-4-nitro-1,2-phenylenediamine 
• 2050-85-3 N,N'-(o-phenylene)di(acetamide) 
• 97-02-9 2,4-Dinitroanilin 
• 108-24-7 acetic anhydride 
• 10268-78-7 1,3-diacetylaminobenzene 
• 34801-09-7 N-(2-aminophenyl)acetamide 
• 22177-15-7 1,2,4-triaminobenzene N¹,N²-diacetate 
• 119-76-6 N,N'-(4-nitro-m-phenylene)-bis-acetamide 

Downstream Products

• 860557-34-2 N,N',N''-(5-nitro-benzene-1,2,4-triyl)-tris-acetamide 
• 56842-62-7 5-acetamido-2-methylbenzimidazole 
• 6635-35-4 1,2,4-triamino-5-nitro-benzene 
• 3204-61-3 1,2,4,5-tetraaminobenzene 

Relevant academic research and scientific papers

Unsymmetrical benzotristhiazole: A new electron-withdrawing core for octupolar chromophores

A six-step synthesis of the unsymmetrical trimethylbenzotristhiazole has been developed. Starting from 2-methylbenzothiazole following nitration, reduction, acetylation, thionation, and twofold cyclization, the desired trimethylbenzotristhiazole was obtained in good yield. Its condensation with donor-substituted benzaldehydes presents the way to new octupolar chromophores. The attempt to synthesize such benzotristhiazole from dinitroaniline failed; this procedure afforded a new benzimidazole derivative.

Novel benzimidazole-based MCH R1 antagonists

The identification of an MCH R1 antagonist screening hit led to the optimization of a class of benzimidazole-based MCH R1 antagonists. Structure-activity relationships and efforts to optimize pharmacokinetic properties are detailed along with the demonstration of the effectiveness of an MCH R1 antagonist in an animal model of obesity.