119-76-6

Basic information

• Product Name: N,N'-(4-nitro-1,3-phenylene)bis(acetamide)
• Synonyms: N,N'-(4-nitro-1,3-phenylene)bis(acetamide);1,3-Bis(acetylamino)-4-nitrobenzene;2,4-Di(acetylamino)-1-nitrobenzene;4-Nitro-N,N'-diacetyl-1,3-benzenediamine;N,N'-Diacetyl-4-nitro-m-phenylenediamine
• CAS NO: 119-76-6
• Molecular Formula: C₁₀H₁₁N₃O₄
• Molecular Weight: 237.21204
• EINECS: 204-349-1
• Mol File: 119-76-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 548.9°Cat760mmHg
• Flash Point: 285.8°C
• Appearance: /
• Density: 1.416g/cm³
• CAS DataBase Reference: N,N'-(4-nitro-1,3-phenylene)bis(acetamide)(CAS DataBase Reference)
• NIST Chemistry Reference: N,N'-(4-nitro-1,3-phenylene)bis(acetamide)(119-76-6)
• EPA Substance Registry System: N,N'-(4-nitro-1,3-phenylene)bis(acetamide)(119-76-6)

Safety Data

• Hazardous Substances Data: 119-76-6(Hazardous Substances Data)

Usage

General Description

N,N'-(4-nitro-1,3-phenylene)bis(acetamide) is a chemical compound with the molecular formula C10H10N4O6. It is a yellow crystalline solid that is soluble in water and polar organic solvents. N,N'-(4-nitro-1,3-phenylene)bis(acetamide) is commonly used as an intermediate in the synthesis of pharmaceuticals and organic compounds. It is also used in research and development for its potential applications in anti-cancer and anti-inflammatory drugs. However, it is important to handle this compound with caution as it may be hazardous to health and the environment.

Upstream product

• 10268-78-7 1,3-diacetylaminobenzene 
• 108-45-2 m-phenylenediamine 
• 5131-58-8 2,4-diaminonitrobenzene 
• 64-19-7 acetic acid 

Downstream Products

• 30120-73-1 1,2,4-triaminobenzene N¹,N²,N⁴-triacetate 
• 56842-62-7 5-acetamido-2-methylbenzimidazole 
• 611-07-4 5-chloro-2-nitrophenol 
• 5131-58-8 2,4-diaminonitrobenzene 
• 16292-86-7 2-hydroxy-4-amino-1-nitrobenzene 
• 91587-57-4 N,N'-(4-chloro-6-nitro-m-phenylene)-bis-acetamide 
• 25781-60-6 1,2,4-triaminobenzene N²,N⁴-diacetate 

Relevant articles and documents

Synthesis and characterization of selected 4,4′-diaminoalkoxyazobenzenes

The role of the -N(CH2CH2OH)2 group in producing a mutagenic response from 4-((3-(2-hydroxyethoxy)4-amino)phenylazo)-N,N-bis(2-hydroxyethyl)aniline has been investigated. To accomplish this goal, a group of substituted 4,4′-diaminoazobenzene dyes was synthesized, and their structures were confirmed using 1H NMR, TOF-LC-ESI mass spectrometry, and combustion analysis. Mutagenicity was determined using the standard Ames test in Salmonella strains TA98, TA100, and TA1538 with and without S9 enzyme activation. The results of this study provide evidence that the mutagenicity of the parent dye arises from the metabolic cleavage of N-hydroxyethyl groups to give the corresponding -NHCH2CH2OH and -NH2 substituted monoazo dyes as direct-acting mutagens. All 5 of the dyes studied were mutagenic at various levels with and without S9 enzyme activation in TA1538. In addition, the results show that removing one N-hydroxyethyl group and capping both -OH groups in the parent dye did not affect mutagenicity, whereas removing both N-hydroxyethyl groups produced a strong direct-acting mutagen in all three bacterial strains. Increasing the length of the N-alkyl chain from two to three carbon atoms eliminated mutagenicity in TA98 without S9 activation.