3017-66-1Relevant articles and documents
Practical regio- and stereoselective azidation and amination of terminal alkenes
Ojo, Olatunji S.,Miranda, Octavio,Baumgardner, Kyle C.,Bugarin, Alejandro
, p. 9354 - 9358 (2019/01/03)
There is significant interest in developing more rapid and efficient production of nitrogen-containing allylic compounds, as widely used in various syntheses. This work reports a variety of allylic azides and allylic amines synthesized by an efficient, new one-pot protocol that employs readily available terminal alkenes as starting materials. This method is highly regio- and stereoselective, affording the linear (E)-isomer, under metal-free conditions. This process tolerates several functional groups including halogen-containing molecules; it is general for azides and amine nucleophiles; and, adducts were obtained in good yields.
Palladium-Catalyzed Synthesis of 2,4-Dienoic Acid Derivatives from Vinylic Halides
Kim, Jin-Il,Patel, Babu A.,Heck, Richard F.
, p. 1067 - 1073 (2007/10/02)
A wide variety of vinylic bromides and iodides have been coupled with acrylic, methacrylic, crotonic, and maleic esters and in some cases with the free acids, nitriles, and amides.In general, good yields of the 2,4-dienoic acid derivatives were obtained.The stereochemistry of the products was determined and the factors influencing the stereoselec-tivity of the reaction were studied.