302586-72-7Relevant academic research and scientific papers
Synthesis of cyclic peptides by ring-closing metathesis
Reichwein, John F.,Versluis, Cornelis,Liskamp, Rob M. J.
, p. 6187 - 6195 (2000)
The synthesis of a series of 'amide to amide' cyclized peptides by ring-closing metathesis (RCM) as well as a convenient synthesis for the linear precursors is described. In addition, the influence of the length of the alkene substituents and the influence of the peptide sequence is investigated, leading to a set of general rules to obtain 'amide to amide' cyclized peptides by RCM.
