30280-44-5

Basic information

• Product Name: 4-CHLOROBENZYL ISOCYANATE 97
• Synonyms: 4-CHLOROBENZYL ISOCYANATE 97;1-chloro-4-(isocyanatoMethyl)benzene;4-Chlorobenzyl isocyanate 97%
• CAS NO: 30280-44-5
• Molecular Formula: C₈H₆ClNO
• Molecular Weight: 167.594
• Product Categories: Isocyanates;Nitrogen Compounds;Organic Building Blocks;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 30280-44-5.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 233-234 °C(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.265 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0493mmHg at 25°C
• Refractive Index: n20/D 1.5460(lit.)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLOROBENZYL ISOCYANATE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLOROBENZYL ISOCYANATE 97(30280-44-5)
• EPA Substance Registry System: 4-CHLOROBENZYL ISOCYANATE 97(30280-44-5)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38-42
• Safety Statements: 23-26-36
• RIDADR: UN 2206PSN2C 6.1 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 30280-44-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6ClNO/c9-8-3-1-7(2-4-8)5-10-6-11/h1-4H,5H2

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 104-86-9 4-chlorobenzylamine 
• 75-44-5 phosgene 
• 140-53-4 p-chlorobenzyl cyanide 
• 873-76-7 para-Chlorobenzyl alcohol 
• 622-95-7 4-chlorobenzyl bromide 
• 1878-66-6 4-chlorophenylacetic Acid 
• 503-38-8 trichloromethyl chloroformate 
• 115601-14-4 4-Chlorphenylacetylazid 

Downstream Products

• 86825-48-1 1-N-(4-Chlorobenzyl)carbamoyl-5-bromopyrimidin-2-one 
• 234102-58-0 4-(4-Aminoquinazolin-7-ylmethyl)-3-oxopiperazine-1-carboxylic acid 4-chloro-benzylamide 
• 143818-80-8 4-[1-(4-Chloro-benzylcarbamoyl)-3,3-diethyl-4-oxo-azetidin-2-yloxy]-benzoic acid 
• 467443-30-7 1-[3-(4-chloro-benzyl)-2,4,5-trioxo-imidazolidin-1-yl]-cyclohexanecarboxylic acid benzyl ester 
• 106663-25-6 3-(4-chlorobenzyl)-1,3-diazaspiro[4.5]decane-2,4-dione 
• 917889-50-0 3-(4-chlorobenzyl)-2,4-dioxoquinazoline-7-carboxylic acid 
• 917889-36-2 methyl 3-(4-chlorobenzyl)-2,4-dioxoquinazoline-7-carboxylate 
• 154871-82-6 methyl 4-[3-(4-chlorobenzyl)-2-oxo-5-oxazolidinyl]methoxybenzoate 
• 467443-12-5 1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid ethyl ester 
• 271598-06-2 5-amino-1-(4-chlorobenzyl)-4-cyano-2-hydroxyimidazole 
• 467443-22-7 1-[3-(4-chloro-benzyl)-ureido]-cyclohexanecarboxylic acid benzyl ester 

Relevant articles and documents

Synthetic method of diflubenzuron impurities for quantitative and qualitative analysis

The invention relates to a synthetic method of diflubenzuron impurities for quantitative and qualitative analysis, and belongs to the technical field of pesticide synthesis. The diflubenzuron impurities are synthesized in the following way, wherein R is t

NOVEL CYCLICSULFONIMIDOYLPURINONE COMPOUNDS AND DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 and n are as described herein, or pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

Design and Synthesis of 4-Alkylidene-β-lactams: Benzyl- and Phenethyl-carbamates as Key Fragments to Switch on Antibacterial Activity

The emergence of multidrug-resistant bacterial strains is particularly important in chronic pathologies such as cystic fibrosis (CF), in which persistent colonization and selection of resistant strains is favored by the frequent and repeated use of antibacterial agents. Staphylococcus aureus is a common pathogen in CF patients that has an associated increased multidrug resistance. In previous studies we demonstrated that the presence of a 4-alkylidene side chain directly linked to a β-lactam appeared to strengthen the potency against S. aureus, especially against methicillin-resistant S. aureus (MRSA) strains. In the present study, 21 new 4-alkylidene-β-lactams were synthesized and evaluated for antibacterial activity. We designed the new compounds to have aryl, benzyl, or phenethyl-carbamate groups on the C3 hydroxyethyl side chain. We found a correlation between biological activity and the nitrogen substituent of the carbamate group, and two phenethyl-carbamate β-lactams were shown to be valuable antibacterial agents against selected linezolid-resistant strains, with a minimum inhibitory concentrations of 2–4 mg L?1.