302938-30-3

Upstream product

• 105-56-6 ethyl 2-cyanoacetate 
• 21487-45-6 1,3-diphenyl-4-formylpyrazole 
• 98-86-2 acetophenone 
• 583-11-9 N-(1-phenylethylidene)phenylhydrazine 
• 100-63-0 phenylhydrazine 

Relevant academic research and scientific papers

Synthesis and anti-rotavirus activity of some nitrogen heterocycles integrated with pyrazole scaffold

Herein, the building block synthon 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl)acryloyl chloride 4 was synthesized and utilized for construction of a wide variety of nitrogen heterocycles encompassing a pyrazole scaffold via treatment with some nitrogen nucle

Synthesis and antimicrobial evaluation of some heterocyclic compounds from 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehydes

A new series of chalcones, pyrazolinyl-pyrazoles, pyrazole-4-carbaldehyde oximes, pyrazole-4-carbonitriles, 5-pyrazolyl-1,2,4-Triazolidine-3-Thiones, and Knoevenagel condensation products was synthesized from 3-Aryl-1-phenyl-1H-pyrazole-4-carbaldehydes. Most reactions were carried out either without solvent or in the presence of water as a green solvent. The structure of synthesized compounds was characterized by spectral and elemental analysis. The synthesized compounds were tested in vitro for their antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans in comparison with imipenem (intravenous β-lactam antibiotic) and clotrimazole (antifungal medication) as reference drugs by using the agar diffusion technique. 3-Aryl-1-phenyl-1H-pyrazole-4-carbonitriles 8b, 8c, and 8d showed significant antifungal activity against the fungus C. albicans.

Synthesis, Reactions and Antitumor Activity of Certain 1,3-diphenylpyrazole-4-carboxaldehyde Derivatives

IN activity continuation especially of our the interest antitumor in synthesis activity.In of novel this paper heterocycles we have with discussed anticipat

Pyrazole based solid state emissive NLOphores with TICT characteristics: Synthesis, DFT and TDDFT studies

A series of pyrazole based D-π-A derivatives with large stokes shift have been synthesized from 1,3-dipheny-1H-pyrazole-3-carbaldehyde by reacting with a series of active methylenes and characterized by spectroscopic analysis. The synthesized dyes show blue to red solid state emissions in the range of 441-604 nm. All the pyrazole dyes, except dye 2.3.6.4-((1,3-dipheny-1H-pyrazole-4-yl)methylene)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one, display solid state emission characteristics. Experimental absorption and emission wavelengths measured for all the synthesized dyes are in good agreement with those predicted using the Time-Dependent Density Functional Theory. In this paper, the static first, second hyperpolarizability and its related properties estimated for pyrazole based "push-pull" dyes using B3LYP functional with 6-311G(d) basis sets. We have performed experimental calculation to determine the first hyperpolarizability using solvatochromic shift method. These dyes show high first hyperpolarizability in the range of 39.96-296.35 × 10-30 esu by theoretical method and 35.8-302 × 10-30 esu by solvatochromic shift method.

A Green and Facile Synthesis of Biopertinent Pyrazole-Decorated Nitriles and Acrylates under Catalyst-Free Conditions

A green and efficient methodology has been developed for the construction of 2-[(1,3-diaryl-4-pyrazolyl)methylene]malononitriles, potent antioxidant molecules, in good to excellent yields in five minutes from 1,3-diarylpyrazole-4-carbaldehydes and malonon

A mechanochemical approach for the construction of carbon-carbon double bonds: Efficient syntheses of aryl/heteroaryl/aliphatic acrylates and nitriles

An efficient method for the construction of carbon-carbon double bond has been developed from aromatic aldehydes and compounds with active methylene moieties in the presence of catalytic amount of solid sodium ethoxide via mechanochemical approach. This c

Thiourea: An efficient and inexpensive catalyst for the Knoevenagel condensation of pyrazole derivates

Thiourea is an inexpensive, efficient and mild catalyst for the synthesis of Knoevenagel condensation of pyrozoles derivate. In the presence of 10 mol% of thiourea, pyrazole aldehyde react with active methylene compound under microwave-assisted solvent-fr