303048-98-8

Usage

Functional Groups

Triazole ring: Provides potential antifungal or antibacterial properties.
Thione group: Also contributes to potential antifungal or antibacterial activity.
Chlorocyclopropyl group: Indicates potential insecticidal or pesticidal properties.
Chlorophenyl group: Suggests additional insecticidal or pesticidal activity.
Hydroxypropyl group: Indicates potential water solubility, enhancing its applicability in various formulations.

Potential Biological Activities

Antifungal: Due to the presence of triazole and thione groups.
Antibacterial: Also attributed to the triazole and thione functional groups.
Insecticidal/Pesticidal: Suggested by the chlorocyclopropyl and chlorophenyl groups.

Applicability

Pharmaceutical: Potential as an antifungal or antibacterial agent.
Agricultural: Possible use as an insecticide or pesticide.
Industrial: Could be utilized in formulations requiring water solubility or biological activity.

Upstream product

• 120983-72-4 1-chlorocyclopropyl-2-chloro-ethan-1-one 
• 199391-98-5 di-{1-[2-(1-chlorocyclopropyl)-3-(2-chloro-phenyl)-2-hydroxy-propyl-1]-1,2,4-triazol-5-yl} disulphide 
• 611-19-8 1-chloro-2-(chloromethyl)benzene 
• 50-00-0 formaldehyd 
• 1147550-11-5 ammonium thiocyanate 
• 122-51-0 orthoformic acid triethyl ester 
• 540-72-7 sodium thiocyanide 
• 149-73-5 trimethyl orthoformate 
• 333-20-0 potassium thioacyanate 
• 222408-91-5 [2-(1-chloro-cycloprop-1-yl)-3-(2-chlorophenyl)-2-hydroxy]-propyl-1-hydrazine 
• 2290-65-5 trimethylsilyl isothiocyanate 
• 139297-65-7 1-(1-chlorocyclopropyl)-2-(2-chlorophenyl)ethanone 
• 222408-90-4 [2-(1-chlorocyclopropyl-1-yl)-1-(2-chlorophenyl)-2-hydroxy-3-propane]-(1,2,4-triazolidine-3-thiol-1-yl) 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 

Downstream Products

• 199105-36-7 sodium salt of 2-(1-chloro-cyclopropyl)-1-(2-chlorophenyl)-3-(5-mercapto-1,2,4-triazol-1-yl)-propan-2-ol 
• 199391-98-5 di-{1-[2-(1-chlorocyclopropyl)-3-(2-chloro-phenyl)-2-hydroxy-propyl-1]-1,2,4-triazol-5-yl} disulphide 
• 199851-46-2 2-(1-chloro-cyclopropyl)-1-(2-chloro-phenyl)-3-(4-methanesulphonyl-5-thiono-4,5-dihydro-1,2,4-triazol-1-yl)-propan-2-ol 
• 199110-67-3 2-(1-chloro-cyclopropyl)-1(2-chlorophenyl)-3-[5-(4-chloro-benzoyl-mercapto)-1,2,4-triazol-1-yl]-propan-2-ol 

Relevant academic research and scientific papers

Preparation method of prothioconazole compound

The invention relates to the field of bactericides, and discloses a preparation method of a prothioconazole compound. The method comprises the steps of 1) reacting a compound with a structure as shown in a formula (1) defined in the description with hydra

AN INDUSTRIAL SCALE PROCESS FOR THE PREPARATION OF PROTHIOCONAZOLE

The present invention relates to an industrial scale process for the preparation of Prothioconazole (I), which is simple, economical, efficient, user and environment friendly, moreover commercially viable with higher yield and greater chemical purity.

Preparation method of prothioconazole

The invention relates to a preparation method of prothioconazole. In order to solve the problems of harsh reaction temperature conditions, excessive reaction steps, inconvenience in amplification operation, more three wastes, low yield and the like in the prior art, the invention provides a preparation method of prothioconazole. The preparation method comprises the steps of reacting [1-(2-chlorphenyl)-2-(1-chlorocyclopropyl)-2-hydroxy]-propylhydrazine with triethyl orthoformate in an organic solvent, and then adding trimethylsilyl isothiocyanate to continuously react to obtain prothioconazole, wherein the reaction equation is shown in the description. According to the preparation method, low-temperature water-free and oxygen-free and high-temperature extreme operation is avoided, a one-pot boiling mode is adopted, the feeding sequence is changed, the yield of an isomer is reduced, trimethylsilyl thiocyanate is used for replacing thiocyanate, the reaction speed is increased, the overall yield of the reaction is greatly increased, consumables and labor cost are reduced, three wastes are reduced, time is shortened, and the method is high in practical value, suitable for industrial production and wide in application prospect.

Synthetic method of prothioconazole

The invention relates to a synthetic method of prothioconazole. The method specifically comprises the following steps: oxidizing an intermediate A by ferric chloride to generate prothioconazole and simultaneously generate ferrous chloride and hydrogen chl

Method for synthesizing triazoline thioketone compound by one-pot method

The invention discloses a method for synthesizing a triazoline thioketone compound by a one-pot method. A triazolidine thioketone compound shown as a formula I is used as a raw material and subjectedto oxidation and reduction to obtain the triazoline thio

Synthesis method and application of prothioconazole

The invention relates to the technical field of chemical drug synthesis, and especially relates to a synthesis method and application of prothioconazole. The synthesis method of prothioconazole comprises the following steps: 1, carrying out an epoxidation reaction on a compound represented by formula IV to obtain a compound represented by formula III; 2, performing nucleophilic addition reaction on the compound of the formula III and triazole to obtain a compound represented by formula II; and 3, carrying out a vulcanization reaction on the compound of the formula II to obtain prothioconazolerepresented by formula I. The prothioconazole is prepared by taking the compound of the formula IV as an initial raw material through the epoxidation reaction, the nucleophilic addition reaction and the vulcanization reaction, so the cost is low, safety and high efficiency are achieved, potential safety hazards are avoided, the overall yield is high, reaction conditions are mild, the raw materialutilization rate is increased, three wastes can be obviously reduced, and the method has certain significance for industrial production.

Continuous flow oxidation method for synthesis of prothioconazole

The invention provides a continuous flow oxidation method for synthesis of prothioconazole, and relates to the field of preparation of bactericides, specifically to the continuous flow oxidation method for synthesis of the prothioconazole. The continuous

Preparation method of prothioconazole

The invention provides a preparation method of prothioconazole. The preparation method comprises steps as follows: A), a compound represented as formula I is subjected to a chlorination cyclization reaction, and a compound represented as formula II is obt