303142-47-4Relevant academic research and scientific papers
Asymmetric transfer hydrogenation of functionalized acetylenic ketones
Fang, Zhijia,Wills, Martin
, p. 8594 - 8605 (2013/09/24)
A systematic study of the asymmetric transfer hydrogenations of functionalized acetylenic ketones and diketones has been completed, together with a total synthesis of (S,S)-(-)-yashabushidiol B. In several cases, excellent enantioselectivities and yields
The Photo-Dehydro-Diels-Alder (PDDA) reaction - A powerful method for the preparation of biaryls
Wessig, Pablo,Mueller, Gunnar,Pick, Charlotte,Matthes, Annika
, p. 464 - 477 (2007/12/27)
The photochemically initiated dehydro-Diels-Alder (PDDA) reaction is an efficient and versatile method for the preparation of biaryls. The ring closure may take place both inter- and intramolecularly, of which the intramolecular variant is more productive
Synthesis and protein degradation capacity of photoactivated enediynes
Fouad, Farid S.,Wright, Justin M.,Plourde II, Gary,Purohit, Ajay D.,Wyatt, Justin K.,El-Shafey, Ahmed,Hynd, George,Crasto, Curtis F.,Lin, Yiqing,Jones, Graham B.
, p. 9789 - 9797 (2007/10/03)
The viability of proteins as targets of thermally and photoactivated enediynes has been confirmed at the molecular level. Model studies using a labeled substrate confirmed the efficacy of atom transfer from diyl radicals produced from enediynes to form captodatively stabilized carbon centered aminoacyl radicals, which then undergo either fragmentation or dimerization. To exploit this finding, a family of enediynes was developed using an intramolecular coupling strategy. Derivatives were prepared and used to target specific proteins, showing good correlation between affinity and photoinduced protein degrading activity. The findings have potential applications in the design of artificial chemical proteases and add to our understanding of the mechanism of action of the clinically important enediyne antitumor antibiotics.
The photo-dehydro-diels-alder reaction: An efficient route to naphthalenes
Wessig, Pablo,Mueller, Gunnar,Kuehn, Andreas,Herre, Robert,Blumenthal, Haiko,Troelenberg, Stefanie
, p. 1445 - 1454 (2007/10/03)
The photo-dehydro-Diels-Alder reaction (PDDA), a new photochemical route to naphthalenes is presented. The [4+2] cycloaddition takes place between 3-arylynones and arylacetylenes. in which these moieties may be located in two molecules (intermolecular PDD
Synthesis of carbonyl and dicarbonyl compounds from organometallic reagents and N-imidazolium-N-methyl amides and bis-amides
De Las Heras, Maria A.,Vaquero, Juan J.,Garcia Navio, Jose L.,Alvarez-Builla, Julio
, p. 14297 - 14310 (2007/10/03)
A new method for the synthesis of selective acylating agents is described from the reaction of carboxylic acids with 3-methyl-1-methylamino-3H-imidazol-1-ium salts in the presence of appropriate coupling reagents. The amides and bis-amides thus prepared reacted selectively with organometallics to afford ketones and diketones and with DIBALH to give aldehydes and dialdehydes in high yields.
