30452-00-7

Upstream product

• 2843-17-6 3-bromo-2,2-dimethylpropionic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 14002-80-3 Methyl 2,2-dimethyl-3-hydroxypropionate 
• 846038-01-5 methyl 2,2-dimethyl-3-((methylsulfonyl)oxy)propanoate 
• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 30451-99-1 1,1-dimethoxy-2,2-dimethylcyclopropane 

Downstream Products

• 598-98-1 Methyl pivalate 
• 796739-73-6 3-(4-bromophenylmethylsulfanyl)-2,2-dimethylpropanoic acid methyl ester 
• 1193335-02-2 3-(4-bromo-2-oxo-2H-pyridin-1-yl)-2,2-dimethyl-propionic acid methyl ester 
• 726206-95-7 C₁₂H₁₆N₂O₅ 
• 726207-22-3 C₂₇H₂₄ClN₃O₈S 
• 726207-23-4 C₂₇H₂₆ClN₃O₆S 
• 1356116-78-3 C₁₂H₁₃F₃O₄S 
• 1356116-30-7 C₁₉H₂₃F₃N₂O₄S 
• 1356116-77-2 C₁₃H₁₅F₃O₂S 
• 1403388-01-1 methyl 3-(5-bromo-1-(cyclohexylmethyl)-2-methyl-1H-pyrrole-3-sulfonamido)-2,2-dimethylpropanoate 
• 738606-46-7 ETC-1002 
• 1357144-86-5 C₂₈H₂₅NO₄ 
• 1357144-84-3 C₂₉H₂₇NO₄ 
• 1357144-83-2 C₂₈H₂₆N₂O₄ 

Relevant academic research and scientific papers

Pyridineacetamide derivative serving as CDK inhibitor, and preparation method and application thereof

The invention belongs to the technical field of pyridineacetamide derivatives, and particularly relates to a pyridineacetamide derivative serving as a CDK inhibitor and a preparation method and application of the pyridine acetamide derivative. The pyridineacetamide derivative shows excellent CDK9/CDK7 enzyme inhibitory activity, and can be used for preparing drugs used for treating cancers, especially hematologic cancers including acute myeloid leukemia, multiple myeloma, chronic lymphocytic leukemia, follicular lymphoma and the like and solid tumors such as breast cancer, prostate cancer, ovarian cancer, hepatocellular carcinoma, pancreatic cancer, kidney cancer, stomach cancer, colorectal cancer, lung cancer and the like.

PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS

The present invention relates to compounds of formula (I): (I) or pharmaceutically acceptable salts thereof, as well as processes for their manufacture, pharmaceutical compositions comprising them, and their use as medicaments.

ISOXAZOLIDINE DERIVED INHIBITORS OF RECEPTOR INTERACTING PROTEIN KINASE 1 (RIPK 1)

The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

SULFONYL COMPOUNDS WHICH MODULATE THE CB2 RECE

Compounds of formula (I) and formula (II) are disclosed. Compounds according to the invention bind to and are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are a

7-Acyl-3-(substituted triazolyl thiomethyl)cephalosporins

The compounds of this invention are cephalosporins having various acyl substituents at the 7-position and a substituted triazolyl thiomethyl group at the 3-position of the cephem nucleus and intermediates for the preparation thereof. The 7-acylated compounds have antibacterial activity.