30516-21-3

Upstream product

• 95-14-7 1,2,3-Benzotriazole 
• 103-80-0 phenylacetyl chloride 
• 103-82-2 phenylacetic acid 
• 37073-15-7 1-(methanesulfonyl)-1H-1,2,3-benzotriazole 
• 4231-62-3 1-benzoyl-1H-benzotriazole 

Downstream Products

• 103-82-2 phenylacetic acid 
• 95-14-7 1,2,3-Benzotriazole 
• 52648-55-2 N-([1,1'-biphenyl]-2-yl)-2-phenylacetamide 
• 103-81-1 Benzeneacetamide 
• 1614-15-9 N,N-bis-benzotriazole 
• 155138-06-0 6-N-Phenylacetyl-2'-deoxyadenosine 
• 92447-25-1 N²-Phenylacetyl-2'-deoxyguanosine 
• 173978-68-2 4-N-Phenylacetyl-2'-deoxycytidine 
• 3389-53-5 phenylacetylpyrrolidine 
• 13196-28-6 2-phenyl-1-(thiophen-2-yl)ethan-1-one 
• 138350-43-3 2-phenyl-1-(5-methyl-2-furyl)-1-ethanone 
• 6876-65-9 N-(4-methylphenyl)-2-phenylacetamide 
• 7500-45-0 N-benzylphenylacetamide 
• 60-12-8 2-phenylethanol 

Relevant academic research and scientific papers

Synthesis and structure-activity relationship studies of cytotoxic anhydrovinblastine amide derivatives

A series of 3-demethoxycarbonyl-3-amide methyl anhydrovinblastine derivatives (5b-24b) was designed, synthesized, and evaluated for their proliferation inhibition activities against two tumor cell lines (A549 and HeLa). Most of the amide anhydrovinblastin

A new methodology for the synthesis of N-acylbenzotriazoles

A facile and economic path for an easy access of diverse N-acylbenzotriazoles from carboxylic acid has been devised using NBS/PPh3 in anhydrous dichloromethane. High yield of product was obtained at room temperature in one hour reaction time under mild reaction conditions.

Exploiting the Imidazolium Effect in Base-free Ammonium Enolate Generation: Synthetic and Mechanistic Studies

N-Acyl imidazoles and catalytic isothiourea hydrochloride salts function as ammonium enolate precursors in the absence of base. Enantioselective Michael addition–cyclization reactions using different α,β-unsaturated Michael acceptors have been performed to form dihydropyranones and dihydropyridinones with high stereoselectivity. Detailed mechanistic studies using RPKA have revealed the importance of the “imidazolium” effect in ammonium enolate formation and have highlighted key differences with traditional base-mediated processes.

Synthesis and structure-activity relationship studies of cytotoxic ester and ether anhydrovinblastine derivatives

Two new series of 3-demethoxycarbonyl-3-ester and 3-demethoxycarbonyl-3- ether methyl anhydrovinblastine derivatives were designed, synthesized, and evaluated for their inhibitory activities against human non-small-cell lung cancer (A549) and cervical epi

C-acylation of 2-methylfuran and thiophene using N-acylbenzotriazoles

Reactions of 2-methylfuran and thiophene with readily available N-acylbenzotriazoles (RCOBt, where R = 4-tolyl, 4-methoxyphenyl, benzyl, 4-nitrophenyl, 4-diethylaminophenyl, 2-pyridyl and 1-naphthyl) in the presence of TiCl4 or ZnBr2 produced 2-methyl-4-acylfurans 2a-e and 2-acylthiophenes 3a-f in average yields of 54 % and 75 %, respectively. Literature yields for the preparation of the same compounds are significantly lower.

N-acylbenzotriazoles: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides

Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) α-hydroxyamides from α-hydroxy acids and of (ii) perfluoroalkylated amides.