30530-44-0

Basic information

• Product Name: 2,4-DIAMINO-6-(4-FLUOROPHENYL)-1,3,5-TRIAZINE
• Synonyms: 2,4-DIAMINO-6-(4-FLUOROPHENYL)-1,3,5-TR&;1,3,5-Triazine-2,4-diaMine, 6-(4-fluorophenyl)-
• CAS NO: 30530-44-0
• Molecular Formula: C₉H₈FN₅
• Molecular Weight: 205.1952
• Product Categories: Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Triazines
• Mol File: 30530-44-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 276-280 °C(lit.)
• Boiling Point: 486.1 °C at 760 mmHg
• Flash Point: 247.8 °C
• Appearance: /
• Density: 1.433 g/cm³
• Vapor Pressure: 1.33E-09mmHg at 25°C
• Refractive Index: 1.671
• PKA: 4.15±0.10(Predicted)
• CAS DataBase Reference: 2,4-DIAMINO-6-(4-FLUOROPHENYL)-1,3,5-TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIAMINO-6-(4-FLUOROPHENYL)-1,3,5-TRIAZINE(30530-44-0)
• EPA Substance Registry System: 2,4-DIAMINO-6-(4-FLUOROPHENYL)-1,3,5-TRIAZINE(30530-44-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 30530-44-0(Hazardous Substances Data)

Usage

General Description

2,4-DIAMINO-6-(4-FLUOROPHENYL)-1,3,5-TRIAZINE is a chemical compound with the molecular formula C9H7N5F. It is a triazine derivative, which is a heterocyclic organic compound containing three nitrogen atoms in the ring. This chemical is commonly used in the synthesis of pharmaceuticals and agrochemicals due to its versatile reactivity. It has been studied for its potential use as an antiviral and anticancer agent. Additionally, it has been used as a building block in the synthesis of various organic compounds in the pharmaceutical and agricultural industries.

InChI:InChI=1/C9H8FN5/c10-6-3-1-5(2-4-6)7-13-8(11)15-9(12)14-7/h1-4H,(H4,11,12,13,14,15)

Upstream product

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Relevant articles and documents

2,4,6-trisubstituted-1,3,5-s-triazine compound and preparation and application thereof

The invention provides a 2,4,6-trisubstituted-1,3,5-s-triazine compound as well as preparation and application thereof, and biguanide or dimethyl biguanide hydrochloride is used as an initial raw material to react with a cyano compound under an alkaline condition to prepare the 2,4,6-trisubstituted-1,3,5-s-triazine compound. The invention provides a simple and convenient synthetic method of a 2,4,6-trisubstituted-1,3,5-s-triazine compound, and the compound provided by the invention can be applied to preparation of an anti-myelogenous leukemia medicine, namely an enasidenib medicine. Compared with the prior art, the method for preparing the enasidenib has the advantages that two-step reaction is reduced, the use of a halogenating reagent is avoided, and the method is a green and environment-friendly chemical process. The structural formula I is shown in the specification.

Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions

The high yielding synthesis of 6-aryl-2,4-diaminopyrimidines and triazines via palladium catalysed Suzuki cross-coupling reactions of commercially available 6-chloro-2,4-diaminopyrimidine 1 or 6-chloro-2,4-diaminotriazine 8 and aryl boronic acids are desc