544710-44-3

Upstream product

• 3460-18-2 1,4-dibromo-2-nitrobenzene 
• 147-93-3 Thiosalicylic acid 
• 200280-46-2 2-(4-bromo-2-nitrophenylsulfanyl) benzoic acid methyl ester 
• 33441-56-4 ethyl 2-mercaptobenzoate 

Downstream Products

• 935433-68-4 2-(2-amino-4-bromophenylsulfanyl) benzoic acid 
• 305352-04-9 5-bromo-2-((2-((dimethylamino)methyl)phenyl)thio)aniline 
• 305351-97-7 N,N-dimethyl-2-[(4-bromo-2-nitrophenyl)thio]benzamide 
• 334632-65-4 N-methyl-2-(4-bromo-2-nitrophenylthio)benzamide 
• 334632-67-6 N-methyl-2-(2-amino-4-bromophenylthio)benzylamine 
• 865168-52-1 2-(4-bromo-2-nitro-phenylsulfanyl)-benzoyl chloride 

Relevant academic research and scientific papers

Method for preparing radiotracer precursor SnADAM

A method for preparing a radiotracer precursor SnADAM is revealed. The method overcomes shortcomings of conventional synthesis methods including lower yield rate and time-consuming. Moreover, Pd/C catalyst and hydrogen gas are used to catalyze reduction reaction for avoiding the generation of a large amount of intermediate products with similar structures. Thus there is no need to perform isolation and purification processes. The yield rate of the intermediate products is also increased so that its impact on the low yield rate of the final product SnADAM is minimized. A part of the reaction is significantly accelerated by using tris(dibenzylideneacetone)-dipalladium(0) (Pd2(dba)3) as a catalyst. Thus the production time of SnADAM is shortened.