30570-16-2

Upstream product

• 60750-37-0 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-phenylpyrimidine-5-carboxylic acid 
• 188780-24-7 5-methoxycarbonyl-6-methyl-4-phenyl-3,4-dihydropyrimidin-2(1H)-one 
• 100-52-7 benzaldehyde 
• 67-64-1 acetone 
• 57-13-6 urea 

Relevant academic research and scientific papers

On water synthesis of the novel 2-oxo-1,2,3,4-tetrahydropyrimidines

A simple on water approach for the synthesis of novel tetrahydropyrimidine (THPM) derivatives has been developed under a green and sustainable fashion. For the first time, a deuterated Biginelli's hybrid was synthesized. Novel THPMs are suitable for further derivatization and could be an excellent toolkit for lead-oriented synthesis and/or cross-coupling reactions.

Synthesis of new pyrimidine, quinazoline and diazatricyclo derivatives by multicomponent reaction and evaluation of their biological activity

A series of new pyrimidine and quinazoline derivatives was synthesized by a Biginelli-like reaction of urea/thiourea, aldehyde, and ketone in the presence of hydrochloric acid as a catalyst. In a similar way, some novel diazatricyclo derivatives were obtained via a Biginelli-like reaction followed by an intramolecular Michael-type addition. The yields of products were reasonable after recrystallization from ethanol. All newly synthesized compounds were characterized using IR and NMR (1H and 13C) spectroscopy and elemental analysis. The antibacterial activity of these compounds was investigated against Staphylococcus aureus (RTCC, 1885), and Escherichia Coli (ATCC, 35922). Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright

Expedient synthesis of 5-unsubstituted 3,4-dihydro pyrimidin-2(1H)-ones

A new procedure for the synthesis of 5-unsubstituted 3,4- dihydropyrimidin-2(1H)-ones is described. Two plausible mechanisms for the key chemical transformation are advanced.