30571-59-6Relevant academic research and scientific papers
Application of molecular mechanics in the total stereochemical elucidation of spicigerolide, a cytotoxic 6-tetraacetyl-oxyheptenyl-5,6-dihydro-α-pyrone from Hyptis spicigera
Pereda-Miranda, Rogelio,Fragoso-Serrano, Mabel,Cerda-García-Rojas, Carlos M
, p. 47 - 53 (2001)
Bioactivity-directed fractionation of the crude extract prepared from the medicinal Mexican plant Hyptis spicigera (Lamiaceae) tested on KB cells led to the isolation of spicigerolide (1). The structure for this novel cytotoxic compound was elucidated as
Regioselective Dehydration of Sugar Thioacetals under Mild Conditions
Szpara, Rachel,Goyder, Alexander,Porter, Michael J.,Hailes, Helen C.,Sheppard, Tom D.
, p. 2488 - 2492 (2021/04/13)
Sugars are abundant in waste biomass, making them sustainable chiral building blocks for organic synthesis. The demand for chiral saturated heterocyclic rings for pharmaceutical applications is increasing as they provide well-defined three-dimensional frameworks that show increased metabolic resistance. A range of sugar thioacetals can be dehydrated selectively at C-2 under mild basic conditions, and the resulting ketene thioacetals can be applied to the production of useful chiral building blocks via further selective dehydration reactions.
Conformational analysis of sulfur-containing 6-deoxy-L-hexose derivatives by molecular modeling and NMR spectroscopy. A theoretical study and experimental evidence of intramolecular nonbonded interactions between sulfur and oxygen
Fragoso-Serrano, Mabel,Guillen-Jaramillo, Georgina,Pereda-Miranda, Rogelio,Cerda-Garcia-Rojas, Carlos M.
, p. 7167 - 7175 (2007/10/03)
6-Deoxy-L-mannose diphenyldithioacetal (1) unexpectedly gave the rearranged products phenyl 3,4-di-O-acetyl-2-S-phenyl-1,2-dithio-6-deoxy-β -L-glucopyranoside (9) and 3,4-di-O-acetyl-2,5-anhydro-6-deoxy-L-glucose diphenyldithioacetal (10) upon treatment w
