Application of molecular mechanics in the total stereochemical elucidation of spicigerolide, a cytotoxic 6-tetraacetyl-oxyheptenyl-5,6-dihydro-α-pyrone from Hyptis spicigera

DOI: 10.1016/S0040-4020(00)00987-X

Source and publish data:

Tetrahedron p. 47 - 53 (2001)

Update date:2022-08-03

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Authors:

Pereda-Miranda, Rogelio

Fragoso-Serrano, Mabel

Cerda-García-Rojas, Carlos M

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Article abstract of DOI:10.1016/S0040-4020(00)00987-X

Bioactivity-directed fractionation of the crude extract prepared from the medicinal Mexican plant Hyptis spicigera (Lamiaceae) tested on KB cells led to the isolation of spicigerolide (1). The structure for this novel cytotoxic compound was elucidated as

Full text of DOI:10.1016/S0040-4020(00)00987-X

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